Unraveling the Enigmatic Origin of Neuroblastoma
- PMID: 33171126
- DOI: 10.1016/j.ccell.2020.10.016
Unraveling the Enigmatic Origin of Neuroblastoma
Abstract
The cell of origin of neuroblastoma is mysterious due to the complexity of neural crest derivatives. In this issue of Cancer Cell, Dong et al. compare the transcriptomes of human embryos, fetal adrenal glands, and neuroblastoma at single-cell level and find a chromaffin cell identity of neuroblastoma.
Copyright © 2020 Elsevier Inc. All rights reserved.
Comment on
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Single-Cell Characterization of Malignant Phenotypes and Developmental Trajectories of Adrenal Neuroblastoma.Cancer Cell. 2020 Nov 9;38(5):716-733.e6. doi: 10.1016/j.ccell.2020.08.014. Epub 2020 Sep 17. Cancer Cell. 2020. PMID: 32946775
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