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Review
. 2020 Oct:54:121-129.
doi: 10.1016/j.coph.2020.09.011. Epub 2020 Nov 7.

RNAi therapeutics: an antiviral strategy for human infections

Anthony D Kelleher  1 , Christina Cortez-Jugo  2 , Francesca Cavalieri  3 , Yijiao Qu  2 , Allan R Glanville  4 , Frank Caruso  2 , Geoff Symonds  5 , Chantelle L Ahlenstiel  6
Affiliations
Review

RNAi therapeutics: an antiviral strategy for human infections

Anthony D Kelleher et al. Curr Opin Pharmacol. 2020 Oct.

Abstract

Gene silencing induced by RNAi represents a promising antiviral development strategy. This review will summarise the current state of RNAi therapeutics for treating acute and chronic human virus infections. The gene silencing pathways exploited by RNAi therapeutics will be described and include both classic RNAi, inducing cytoplasmic mRNA degradation post-transcription and novel RNAi, mediating epigenetic modifications at the transcription level in the nucleus. Finally, the challenge of delivering gene modifications via RNAi will be discussed, along with the unique characteristics of respiratory versus systemic administration routes to highlight recent advances and future potential of RNAi antiviral treatment strategies.

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