Application of Mesenchymal Stem Cells in Inflammatory and Fibrotic Diseases

doi:10.3390/ijms21218366

Review

. 2020 Nov 7;21(21):8366.

doi: 10.3390/ijms21218366.

Application of Mesenchymal Stem Cells in Inflammatory and Fibrotic Diseases

Jae-Sung Ryu^{1

2}, Eun-Jeong Jeong^{3

4}, Jong-Yeup Kim^{1

2}, Soon Ju Park^{3

5}, Won Seok Ju^{3

5}, Chang-Hyun Kim⁶, Jang-Seong Kim^{4

7}, Young-Kug Choo^{3

5}

Affiliations

¹ Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Konyang University, Daejeon 35365, Korea.
² Department of Biomedical Informatics, College of Medicine, Konyang University, Daejeon 35365, Korea.
³ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan 54538, Korea.
⁴ Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
⁵ Institute for Glycoscience, Wonkwang University, Iksan 54538, Korea.
⁶ College of Medicine, Dongguk University, Goyang 10326, Korea.
⁷ Department of Functional Genomics, University of Science and Technology (UST), Daejeon 34141, Korea.

PMID: 33171878
PMCID: PMC7664655
DOI: 10.3390/ijms21218366

Review

Application of Mesenchymal Stem Cells in Inflammatory and Fibrotic Diseases

Jae-Sung Ryu et al. Int J Mol Sci. 2020.

. 2020 Nov 7;21(21):8366.

doi: 10.3390/ijms21218366.

Authors

Jae-Sung Ryu^{1

2}, Eun-Jeong Jeong^{3

4}, Jong-Yeup Kim^{1

2}, Soon Ju Park^{3

5}, Won Seok Ju^{3

5}, Chang-Hyun Kim⁶, Jang-Seong Kim^{4

7}, Young-Kug Choo^{3

5}

Affiliations

¹ Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Konyang University, Daejeon 35365, Korea.
² Department of Biomedical Informatics, College of Medicine, Konyang University, Daejeon 35365, Korea.
³ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan 54538, Korea.
⁴ Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
⁵ Institute for Glycoscience, Wonkwang University, Iksan 54538, Korea.
⁶ College of Medicine, Dongguk University, Goyang 10326, Korea.
⁷ Department of Functional Genomics, University of Science and Technology (UST), Daejeon 34141, Korea.

PMID: 33171878
PMCID: PMC7664655
DOI: 10.3390/ijms21218366

Abstract

Mesenchymal stem cells (MSCs) are multipotent stem cells that can be isolated from various tissues in the adult body. MSCs should be characterized by three criteria for regenerative medicine. MSCs must (1) adhere to plastic surfaces, (2) express specific surface antigens, and (3) differentiate into mesodermal lineages, including chondrocytes, osteoblasts, and adipocytes, in vitro. Interestingly, MSCs have immunomodulatory features and secrete trophic factors and immune receptors that regulate the microenvironment in host tissue. These specific and unique therapeutic properties make MSCs ideal as therapeutic agents in vivo. Specifically, pre-clinical and clinical investigators generated inflammatory and fibrotic diseases models, and then transplantation of MSCs into diseases models for therapeutic effects investigation. In this review, we characterize MSCs from various tissues and describe their applications for treating various inflammation and fibrotic diseases.

Keywords: fibrotic disease; inflammatory disease; mesenchymal stem cells (MSCs); paracrine factors.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Characteristics and source of isolation of human mesenchymal stem cells (hMSCs).

See this image and copyright information in PMC

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References

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[1] Wei X., Yang X., Han Z.P., Qu F.F., Shao L., Shi Y.F. Mesenchymal stem cells: A new trend for cell therapy. Acta Pharm. Sin. 2013;34:747–754. doi: 10.1038/aps.2013.50. - DOI - PMC - PubMed

[2] Wei X., Yang X., Han Z.P., Qu F.F., Shao L., Shi Y.F. Mesenchymal stem cells: A new trend for cell therapy. Acta Pharm. Sin. 2013;34:747–754. doi: 10.1038/aps.2013.50. - DOI - PMC - PubMed

[3] Bongso A., Richards M. History and perspective of stem cell research. Best Pr. Res. Clin. Obs. Gynaecol. 2004;18:827–842. doi: 10.1016/j.bpobgyn.2004.09.002. - DOI - PubMed

[4] Bongso A., Richards M. History and perspective of stem cell research. Best Pr. Res. Clin. Obs. Gynaecol. 2004;18:827–842. doi: 10.1016/j.bpobgyn.2004.09.002. - DOI - PubMed

[5] Ilic D., Polak J.M. Stem cells in regenerative medicine: Introduction. Br. Med. Bull. 2011;98:117–126. doi: 10.1093/bmb/ldr012. - DOI - PubMed

[6] Ilic D., Polak J.M. Stem cells in regenerative medicine: Introduction. Br. Med. Bull. 2011;98:117–126. doi: 10.1093/bmb/ldr012. - DOI - PubMed

[7] Evans M.J., Kaufman M.H. Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981;292:154–156. doi: 10.1038/292154a0. - DOI - PubMed

[8] Evans M.J., Kaufman M.H. Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981;292:154–156. doi: 10.1038/292154a0. - DOI - PubMed

[9] Thomson J.A., Itskovitz-Eldor J., Shapiro S.S., Waknitz M.A., Swiergiel J.J., Marshall V.S., Jones J.M. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282:1145–1147. doi: 10.1126/science.282.5391.1145. - DOI - PubMed

[10] Thomson J.A., Itskovitz-Eldor J., Shapiro S.S., Waknitz M.A., Swiergiel J.J., Marshall V.S., Jones J.M. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282:1145–1147. doi: 10.1126/science.282.5391.1145. - DOI - PubMed

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Application of Mesenchymal Stem Cells in Inflammatory and Fibrotic Diseases

Affiliations

Application of Mesenchymal Stem Cells in Inflammatory and Fibrotic Diseases

Authors

Affiliations

Abstract

Conflict of interest statement

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