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Review
. 2020 Nov 6;12(11):2620.
doi: 10.3390/polym12112620.

Polymeric Drug Delivery Systems Bearing Cholesterol Moieties: A Review

Paweł Misiak  1 , Karolina H Markiewicz  1 , Dawid Szymczuk  1 , Agnieszka Z Wilczewska  1
Affiliations
Review

Polymeric Drug Delivery Systems Bearing Cholesterol Moieties: A Review

Paweł Misiak et al. Polymers (Basel). .

Abstract

This review aims to provide an overview of polymers comprising cholesterol moiety/ies designed to be used in drug delivery. Over the last two decades, there have been many papers published in this field, which are summarized in this review. The primary focus of this article is on the methods of synthesis of polymers bearing cholesterol in the main chain or as side chains. The data related to the composition, molecular weight, and molecular weight distribution of polymers are presented. Moreover, other aspects, such as forms of carriers, types of encapsulated drugs, encapsulation efficiency and capacity, are also included.

Keywords: cholesterol; drug delivery; drug encapsulation; encapsulation capacity; encapsulation efficiency; polymers comprising cholesteryl moiety.

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Conflict of interest statement

All authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The structural formula of cholesterol and interaction in lipid bilayer.
Figure 2
Figure 2
Methods of synthesis of polymers containing cholesteryl moieties.
Figure 3
Figure 3
Polymerization methods used for the synthesis of cholesterol end-capped polymers and reaction examples [24,52,54,91,99,100,101].
Figure 4
Figure 4
Post-modification reactions used to introduce cholesteryl moieties at the end of the polymeric chain [27,58,69,74].
Figure 5
Figure 5
Types of polymerization used to obtain polymers with cholesterol moieties as side chains, and reaction examples [30,32,34,35,36].
Figure 6
Figure 6
Methods of incorporation of cholesteryl moieties to side chains by post-polymerization reactions [20,38,39,80,130,132,133].
Figure 7
Figure 7
Forms of drug carriers obtained from polymers bearing cholesteryl moiety/ies.
See this image and copyright information in PMC

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