Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Nov 6;12(11):2620.
doi: 10.3390/polym12112620.

Polymeric Drug Delivery Systems Bearing Cholesterol Moieties: A Review

Paweł Misiak  1 , Karolina H Markiewicz  1 , Dawid Szymczuk  1 , Agnieszka Z Wilczewska  1
Affiliations
Review

Polymeric Drug Delivery Systems Bearing Cholesterol Moieties: A Review

Paweł Misiak et al. Polymers (Basel). .

Abstract

This review aims to provide an overview of polymers comprising cholesterol moiety/ies designed to be used in drug delivery. Over the last two decades, there have been many papers published in this field, which are summarized in this review. The primary focus of this article is on the methods of synthesis of polymers bearing cholesterol in the main chain or as side chains. The data related to the composition, molecular weight, and molecular weight distribution of polymers are presented. Moreover, other aspects, such as forms of carriers, types of encapsulated drugs, encapsulation efficiency and capacity, are also included.

Keywords: cholesterol; drug delivery; drug encapsulation; encapsulation capacity; encapsulation efficiency; polymers comprising cholesteryl moiety.

PubMed Disclaimer

Conflict of interest statement

All authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The structural formula of cholesterol and interaction in lipid bilayer.
Figure 2
Figure 2
Methods of synthesis of polymers containing cholesteryl moieties.
Figure 3
Figure 3
Polymerization methods used for the synthesis of cholesterol end-capped polymers and reaction examples [24,52,54,91,99,100,101].
Figure 4
Figure 4
Post-modification reactions used to introduce cholesteryl moieties at the end of the polymeric chain [27,58,69,74].
Figure 5
Figure 5
Types of polymerization used to obtain polymers with cholesterol moieties as side chains, and reaction examples [30,32,34,35,36].
Figure 6
Figure 6
Methods of incorporation of cholesteryl moieties to side chains by post-polymerization reactions [20,38,39,80,130,132,133].
Figure 7
Figure 7
Forms of drug carriers obtained from polymers bearing cholesteryl moiety/ies.
See this image and copyright information in PMC

References

    1. Wilczewska A.Z., Niemirowicz K., Markiewicz K.H., Car H. Nanoparticles as drug delivery systems. Pharmacol. Rep. 2012;64:1020–1037. doi: 10.1016/S1734-1140(12)70901-5. - DOI - PubMed
    1. Kalepu S., Nekkanti V. Insoluble drug delivery strategies: Review of recent advances and business prospects. Acta Pharm. Sin. B. 2015;5:442–453. doi: 10.1016/j.apsb.2015.07.003. - DOI - PMC - PubMed
    1. Jelonek K., Kasperczyk J. Polyesters and polyester carbonates for controlled drug delivery. Part II. Implantable systems. Polimery. 2013;58:858–863. doi: 10.14314/polimery.2013.858. - DOI
    1. Jones D. Pharmaceutical Applications of Polymers for Drug Delivery. Rapra Technology; Shrewsbury, UK: 2004. Rapra Review Reports.
    1. Nakielski P. Drug Release Systems Based on Nanofibers. IPPT PAN; Warsaw, Poland: 2015. IPPT Reports on Fundamental Technological Research.

LinkOut - more resources