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Review
. 2021;17(4):e230421187786.
doi: 10.2174/1573403X16666201110125906.

Nigella Sativa (Black Seeds), A Potential Herb for the Pharmacotherapeutic Management of Hypertension - A Review

Naina M P Maideen  1 , Rajkapoor Balasubramanian  2 , Sambathkumar Ramanathan  2
Affiliations
Review

Nigella Sativa (Black Seeds), A Potential Herb for the Pharmacotherapeutic Management of Hypertension - A Review

Naina M P Maideen et al. Curr Cardiol Rev. 2021.

Abstract

Hypertension is one of the leading risk factors for stroke, myocardial infarction and untimely death. The prevalence of hypertension is extremely high among the global population, and many of them depend on modern medicines to manage their blood pressure. The modern antihypertensive medications include angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), calcium channel blockers (CCBs), diuretics, beta-adrenergic blockers, direct renin inhibitors, direct-acting vasodilators, alpha-adrenergic blockers and centrally acting drugs that are associated with many harmful and undesirable effects. The patients may consider traditional herbal medicines as a good strategy to manage chronic conditions due to the reasons such as perceived failure of allopathic medicines, relatively high cost of allopathic medicines, social-cultural practices and/or herbal knowledge, poor access to medical facilities and safety concerns about modern medicines. Nigella sativa (Black seeds) has been used to treat various conditions, including hypertension, obesity, diabetes, cancer, etc. Hence, the antihypertensive potential of N. sativa is analyzed in this review. The literature was searched in databases including Medline/PMC/PubMed, Google Scholar, ScienceDirect, Directory of Open Access Journals (DOAJ) and reference lists to identify articles associated with antihypertensive properties of N.sativa. Numerous randomized controlled trials and animal studies reported that N.sativa has potential antihypertensive effects. Hence, N. sativa could be used effectively to manage patients with stage 1 hypertension, and the patients using modern antihypertensive medications could reduce their doses by adding N. sativa into their regimen as adjuvant therapy.

Keywords: Nigella sativa; black seeds; hypertension; kalonji; nigellone.; thymol; thymoquinone.

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Figures

Fig. (1)
Fig. (1)
Probable antihypertensive mechanisms of N. sativa.
See this image and copyright information in PMC

References

    1. Bromfield S., Muntner P. High blood pressure: the leading global burden of disease risk factor and the need for worldwide prevention programs. Curr. Hypertens. Rep. 2013;15(3):134–136. doi: 10.1007/s11906-013-0340-9. - DOI - PMC - PubMed
    1. Mayet J., Hughes A. Cardiac and vascular pathophysiology in hypertension. Heart. 2003;89(9):1104–1109. doi: 10.1136/heart.89.9.1104. - DOI - PMC - PubMed
    1. Vaz N.P., De Oliveira D.R., Abouelella G.A., Khater H.F. In: In: "Metabolic Disorders: Hypertension" of the Series “Recent Progress in Medicinal Plants”. Houston: Studium Press LLC 2018; 48. Govil J.N., editor. Vol. 48 Houston: Studium Press LLC; 2018. The black seed, Nigella sativa (Ranunculaceae), for prevention and treatment of hypertension.
    1. Kearney P.M., Whelton M., Reynolds K., Muntner P., Whelton P.K., He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365(9455):217–223. doi: 10.1016/S0140-6736(05)17741-1. - DOI - PubMed
    1. NCD Risk Factor Collaboration (NCD-RisC) Worldwide trends in blood pressure from 1975 to 2015: A pooled analysis of 1479 population-based measurement studies with 19·1 million participants. Lancet. 2017;389(10064):37–55. doi: 10.1016/S0140-6736(16)31919-5. - DOI - PMC - PubMed

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