Editorial Commentary: Mesenchymal Stem Cell Preparation Methods Affect the Properties of Shoulder Subacromial Bursa-Derived Cells

Abstract

Augmentation of mesenchymal stem cells (MSCs) from the subacromial bursa in the setting of irreparable rotator cuff tears is a powerful candidate for future regenerative medicine. However, little is known about whether the preparation technique affects the individual differences and potentials of subacromial bursa-derived MSCs. The yields obtained by chopping or cell-expansion techniques with a high-density of initial nucleated cells seem to be lower than those obtained with low-density cell-expansion techniques. Differences in cell-preparation methods may affect whether individual differences in their properties exist. Further studies are required using a low-density cell-expansion technique to establish a new regenerative treatment using subacromial bursa-derived MSCs for irreparable rotator cuff tears.