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. 2020 Nov 10;10(1):19421.
doi: 10.1038/s41598-020-76427-1.

Early vascular ageing biomarkers in osteoporotic outpatients: a pilot study

Agostino Gaudio  1   2 , Anastasia Xourafa  3 , Luca Zanoli  3 , Rosario Rapisarda  3 , Antonino Catalano  4 , Salvatore Santo Signorelli  3 , Pietro Castellino  3
Affiliations

Early vascular ageing biomarkers in osteoporotic outpatients: a pilot study

Agostino Gaudio et al. Sci Rep. .

Abstract

Osteoporosis and atherosclerosis are significant public health problems that often coexist, especially in the elderly. Although some studies have reported an age-dependent relationship, others have suggested a causal relationship between osteoporosis and atherosclerosis. The aim of our study was to evaluate the cardiovascular risk in a population of patients with osteoporosis by measuring carotid intima-media thickness (cIMT) and carotid-femoral pulse wave velocity (cf-PWV). A total of 58 patients with osteoporosis and an equal number of healthy control subjects were enrolled. All subjects underwent (1) a bone densitometry examination using dual X-ray absorptiometry, (2) a vascular evaluation for the measurements of cIMT and cf-PWV and (3) a blood sample for the evaluation of lipids and phosphocalcic metabolism. Patients with osteoporosis had a significant increase in cIMT and cf-PWV. There was also a significant inverse correlation between the femoral neck BMD and cf-PWV values. In conclusion, osteoporotic outpatients have earlier vascular ageing, with an increase of arterial stiffness. These data support a possible association between osteoporosis and atherosclerosis independent of age.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Correlation between carotid-femoral PWV and age. PWV: pulse wave velocity. This figure was created using NCSS 2007 and PASS 11 software version 07.1.21 (Gerry Hintze, Kaysville, UT, USA; www.ncss.com).
Figure 2
Figure 2
Correlation between carotid-femoral PWV and femoral neck BMD in all patients with osteoporosis (A) and in female patients with osteoporosis (B). PWV: pulse wave velocity; BMD: bone mineral density. This figure was created using NCSS 2007 and PASS 11 software version 07.1.21 (Gerry Hintze, Kaysville, UT, USA; www.ncss.com).
See this image and copyright information in PMC

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