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Review
. 2021 Jan;20(1):21-38.
doi: 10.1038/s41573-020-0088-2. Epub 2020 Nov 10.

Therapeutic strategies targeting FOXO transcription factors

Giampaolo Calissi  1 , Eric W-F Lam  2 , Wolfgang Link  3
Affiliations
Review

Therapeutic strategies targeting FOXO transcription factors

Giampaolo Calissi et al. Nat Rev Drug Discov. 2021 Jan.

Abstract

FOXO proteins are transcription factors that are involved in numerous physiological processes and in various pathological conditions, including cardiovascular disease, cancer, diabetes and chronic neurological diseases. For example, FOXO proteins are context-dependent tumour suppressors that are frequently inactivated in human cancers, and FOXO3 is the second most replicated gene associated with extreme human longevity. Therefore, pharmacological manipulation of FOXO proteins is a promising approach to developing therapeutics for cancer and for healthy ageing. In this Review, we overview the role of FOXO proteins in health and disease and discuss the pharmacological approaches to modulate FOXO function.

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