Small molecule targets toxic RNA repeats

Comment

Sarah Crunkhorn. Nat Rev Drug Discov. 2021 Jan.

. 2021 Jan;20(1):20.

doi: 10.1038/d41573-020-00203-z.

No abstract available

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A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex.
Angelbello AJ, Benhamou RI, Rzuczek SG, Choudhary S, Tang Z, Chen JL, Roy M, Wang KW, Yildirim I, Jun AS, Thornton CA, Disney MD. Angelbello AJ, et al. Cell Chem Biol. 2021 Jan 21;28(1):34-45.e6. doi: 10.1016/j.chembiol.2020.10.007. Epub 2020 Nov 5. Cell Chem Biol. 2021. PMID: 33157036 Free PMC article.

1. Angelbello, A. J. et al. A small molecule that binds an RNA repeat expansion stimulates its decay via the exosome complex. Cell Chem. Biol. https://doi.org/10.1016/j.chembiol.2020.10.007 (2020)