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. 2020 Oct;27(5):257-262.
doi: 10.3747/co.27.5963. Epub 2020 Oct 1.

A clinical investigation of the association between perioperative oral management and prognostic nutritional index in patients with digestive and urinary cancers

H Otagiri  1 , S Yamadav  1 , M Hashidume  1 , A Sakurai  1 , M Morioka  1 , E Kondo  1 , H Sakai  1 , H Kurita  1
Affiliations

A clinical investigation of the association between perioperative oral management and prognostic nutritional index in patients with digestive and urinary cancers

H Otagiri et al. Curr Oncol. 2020 Oct.

Abstract

Background: The prognostic nutritional index (pni) is a simple metric calculated using serum albumin and the peripheral lymphocyte count. It was reported that a low pni score is significantly associated with major postoperative complications and poor prognosis. The purpose of the present study was to investigate the effects of perioperative oral management (pom) on the perioperative pni profiles of patients with digestive system or urinary cancers.

Study design: The medical records of 181 patients with cancer who underwent surgery and for whom a pni could be calculated were retrospectively reviewed.

Results: The intervention rate with pom was 34.8%. The median preoperative pni score was 48.25 in all patients with a pom intervention [25% to 75% interquartile range (iqr): 44.38-54.13] and 47.25 in those without an intervention (iqr: 42.0-53.5). Compared with patients not receiving pom, those who received pom had significantly higher pni scores from the early postoperative period (p < 0.05). Notably, of patients who could resume oral intake within 3 days after surgery, those who received pom intervention, compared with those who did not, had significantly higher pni scores from the early postoperative period (p < 0.05).

Conclusions: Perioperative oral management interventions might have positive effects on the postoperative pni scores of patients with cancer.

Keywords: C-reactive protein; Perioperative oral management; crp; digestive cancer; prognostic nutritional index; serum albumin; urinary cancer.

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Conflict of interest statement

CONFLICT OF INTEREST DISCLOSURES We have read and understood Current Oncology’s policy on disclosing conflicts of interest, and we declare that we have none.

Figures

FIGURE 1
FIGURE 1
Perioperative change of the prognostic nutritional index (PNI) profile in 181 patients. Compared with those who did not receive perioperative oral management (POM) interventions, those who did had significantly higher PNI scores from the early postoperative period (p < 0.05).
FIGURE 2
FIGURE 2
Perioperative change of the prognostic nutritional index (PNI) profile in 74 patients with digestive system cancers and 107 patients with urologic cancers. Perioperative PNI scores were not significantly different in patients who received perioperative oral management (POM) and in those who did not (digestive cancer: p = 0.709; urologic cancer: p = 0.596).
FIGURE 3
FIGURE 3
Perioperative change of the prognostic nutritional index (PNI) profile in 142 patients who could resume oral intake by postoperative day 3. Of the patients who could resume oral intake within 3 days postoperatively, PNI scores were significantly higher for those who received perioperative oral management (POM) from the early postoperative period, compared with those who did not (p < 0.05).
See this image and copyright information in PMC

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