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. 1987 Dec;84(23):8325-9.
doi: 10.1073/pnas.84.23.8325.

Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells

D A Holtzman  1 , W D Cook, A R Dunn
Affiliations

Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells

D A Holtzman et al. Proc Natl Acad Sci U S A. 1987 Dec.

Abstract

We have isolated a murine cDNA that shares extensive homology with genes encoding the src (Rous sarcoma virus oncogene)-related family of protein-tyrosine kinases. The cDNA includes an open reading frame of 1509 base pairs, and conceptual translation predicts a protein of 56 kDa. Blot-hybridization analysis indicates that this src-related gene is expressed in normal macrophages and in cell lines representing both the myeloid and lymphoid B-cell lineages and, accordingly, is designated "bmk" (B cell/myeloid kinase). In addition, bmk mRNA levels increase following the induced differentiation of the murine myelomonocytic leukemic cell line WEHI-3B.

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References

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