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Review
. 2020 Nov;47(11):9189-9199.
doi: 10.1007/s11033-020-05963-w. Epub 2020 Nov 10.

Emerging role of N4-acetylcytidine modification of RNA in gene regulation and cellular functions

R Karthiya  1 , S Mohammed Wasil  1 , Piyush Khandelia  2
Affiliations
Review

Emerging role of N4-acetylcytidine modification of RNA in gene regulation and cellular functions

R Karthiya et al. Mol Biol Rep. 2020 Nov.

Abstract

Post-transcriptional chemical modification of RNA is rapidly emerging as a key player in regulating gene expression and has propelled the development of 'epitranscriptomics' or 'RNA epigenetics' as a frontier area of research. Several RNA modifications are known to decorate RNAs and impact its structure and function. One such recently discovered modification is acetylation of RNA i.e. N4-acetylcytidine (ac4C) chemical modification. N4-acetylcytidine is an ancient and evolutionarily conserved modification, which maps to a wide spectrum of RNAs from archaea bacteria to humans. This modification results in a variety of functional outcomes which impact normal development and disease. In this review, we summarize the recent progress, emerging methods, biological implications and the future challenges for ac4C modification.

Keywords: Gene regulation; N4-acetylcytidine; RNA acetylation; RNA modification; ac4C.

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