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Comment
. 2020 Dec 5;143(11):e97.
doi: 10.1093/brain/awaa306.

Aggressive multiple sclerosis: a matter of measurement and timing

David Ellenberger  1 , Peter Flachenecker  2 , Firas Fneish  1 , Niklas Frahm  1   3 , Kerstin Hellwig  4 , Friedemann Paul  5 , Alexander Stahmann  1 , Clemens Warnke  6 , Paulus S Rommer  3   7 , Uwe K Zettl  3
Affiliations
Comment

Aggressive multiple sclerosis: a matter of measurement and timing

David Ellenberger et al. Brain. .
No abstract available

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Figures

Figure 1
Figure 1
Aggressive multiple sclerosis according to various definitions. (A) Proportions of aggressive multiple sclerosis (MS) patients over time according to different definitions. In this interval-censored Cox model, the rising proportions of patients in the GMSR classified as aggressive multiple sclerosis according to the definitions of Freedman and Rush (2016), Díaz et al. (2019), Spelman et al. (2020), Gholipour et al. (2011), Menon et al. (2017), Tintore et al. (2019) and Malpas et al. (2020) (10 years) were presented depending on the disease duration from symptom onset. Additionally, the proportion of early retired patients in the first 5 years is given. (B) Venn diagram showing overlapping proportions of aggressive multiple sclerosis patients according to various definitions in the first 5 years of the disease (n = 752). Comparison of aggressive multiple sclerosis patients according to Freedman and Rush (2016) (F) Díaz et al. (2019), Gholipour et al. (2011) (G) Menon et al. (2017), Spelman et al. (2020) (S) and the early retired (ER) patients with aggressive multiple sclerosis.
See this image and copyright information in PMC

Comment in

Comment on

  • Early clinical markers of aggressive multiple sclerosis.
    Malpas CB, Manouchehrinia A, Sharmin S, Roos I, Horakova D, Havrdova EK, Trojano M, Izquierdo G, Eichau S, Bergamaschi R, Sola P, Ferraro D, Lugaresi A, Prat A, Girard M, Duquette P, Grammond P, Grand'Maison F, Ozakbas S, Van Pesch V, Granella F, Hupperts R, Pucci E, Boz C, Sidhom Y, Gouider R, Spitaleri D, Soysal A, Petersen T, Verheul F, Karabudak R, Turkoglu R, Ramo-Tello C, Terzi M, Cristiano E, Slee M, McCombe P, Macdonell R, Fragoso Y, Olascoaga J, Altintas A, Olsson T, Butzkueven H, Hillert J, Kalincik T. Malpas CB, et al. Brain. 2020 May 1;143(5):1400-1413. doi: 10.1093/brain/awaa081. Brain. 2020. PMID: 32386427

References

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    1. Malpas CB, Manouchehrinia A, Sharmin S, Roos I, Horakova D, Havrdova EK, et al.Early clinical markers of aggressive multiple sclerosis. Brain J Neurol 2020; 143: 1400–13. - PubMed