Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021

Abstract

The National Genomics Data Center (NGDC), part of the China National Center for Bioinformation (CNCB), provides a suite of database resources to support worldwide research activities in both academia and industry. With the explosive growth of multi-omics data, CNCB-NGDC is continually expanding, updating and enriching its core database resources through big data deposition, integration and translation. In the past year, considerable efforts have been devoted to 2019nCoVR, a newly established resource providing a global landscape of SARS-CoV-2 genomic sequences, variants, and haplotypes, as well as Aging Atlas, BrainBase, GTDB (Glycosyltransferases Database), LncExpDB, and TransCirc (Translation potential for circular RNAs). Meanwhile, a series of resources have been updated and improved, including BioProject, BioSample, GWH (Genome Warehouse), GVM (Genome Variation Map), GEN (Gene Expression Nebulas) as well as several biodiversity and plant resources. Particularly, BIG Search, a scalable, one-stop, cross-database search engine, has been significantly updated by providing easy access to a large number of internal and external biological resources from CNCB-NGDC, our partners, EBI and NCBI. All of these resources along with their services are publicly accessible at https://bigd.big.ac.cn.

Figure 1.

Core data resources of CNCB-NGDC. Three categories, viz., data, information and knowledge, are adopted to represent resources that are typically to deposit raw data/metadata (archives), house value-added information (databases) and integrate validated knowledge through literature curation (knowledgebases), respectively. A full list of data resources, which contains links to each resource, is available at https://bigd.big.ac.cn/databases.

Figure 2.

Statistics of data submissions to BioProject, BioSample and GSA. (A) Data statistics of BioProject and BioSample. (B) Data statistics of Experiments and Runs as well as file size in GSA. All statistics are frequently updated and publicly available at https://bigd.big.ac.cn/bioproject, https://bigd.big.ac.cn/biosample and https://bigd.big.ac.cn/gsa.