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. 2020 Nov 11;15(11):e0242184.
doi: 10.1371/journal.pone.0242184. eCollection 2020.

Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients

Affiliations

Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients

Daniel Camprubí et al. PLoS One. .

Erratum in

Abstract

Ivermectin has recently shown efficacy against SARS-CoV-2 in-vitro. We retrospectively reviewed severe COVID-19 patients receiving standard doses of ivermectin and we compared clinical and microbiological outcomes with a similar group of patients not receiving ivermectin. No differences were found between groups. We recommend the evaluation of high-doses of ivermectin in randomized trials against SARS-CoV-2.

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Conflict of interest statement

The authors have declared that no competing interests exist.

References

    1. The RECOVERY Collaborative Group. Dexamethasone in Hospitalized Patients with Covid-19—Preliminary Report. New Engl J Med. 2020. 10.1056/NEJMoa2021436 - DOI - PMC - PubMed
    1. Beigel JH, Tomashek KM, Dodd LE, et al. Remdesivir for the treatment of Covid-19—preliminary report. New Engl J Med. 2020. May 22 10.1056/NEJMoa2007764 - DOI - PubMed
    1. Sanders JM, Monogue ML, Jodlowski TZ, Cutrell JB. Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review. JAMA. 2020. 10.1001/jama.2020.6019 - DOI - PubMed
    1. Caly L, Druce JD, Catton MG, Jans DA, Wagstaff KM. The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Res. 2020:104787 10.1016/j.antiviral.2020.104787 - DOI - PMC - PubMed
    1. Chaccour C, Hamman F, Ramón-García S, Rabinovich NR. Ivermectin and Novel Coronavirus Disease (COVID-19): Keeping Rigor in Times of Urgency. Am J Trop Med Hyg. 2020;00(0):1–2. - PMC - PubMed

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