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Comment
. 2020 Dec 5;143(11):e95.
doi: 10.1093/brain/awaa302.

rs34331204 regulates TSPAN13 expression and contributes to Alzheimer's disease with sex differences

Yang Hu  1 , Haihua Zhang  2 , Bian Liu  3 , Shan Gao  2 , Tao Wang  4   5 , Zhifa Han  6   7   8 ; International Genomics of Alzheimer’s Project (IGAP); Xunming Ji  2   3   9   10 , Guiyou Liu  2   3   10
Affiliations
Comment

rs34331204 regulates TSPAN13 expression and contributes to Alzheimer's disease with sex differences

Yang Hu et al. Brain. .
No abstract available

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Figures

Figure 1
Figure 1
A box plot showing the expression of the six genes across the 10 brain tissues in Braineac. (A) Fold change between OCTX and WHMT = 5.8 (P = 2.20 × 10−64) for TSPAN13; (B) fold change between WHMT and CRBL = 3 (P = 2.30 × 10−68) for AHR; (C) fold change between TCTX and WHMT = 2 (P = 8.80 × 10−44) for ANKMY2; (D) fold change between PUTM and MEDU = 2 (P = 1.00 × 10−37) for BZW2; (E) fold change between TCTX and MEDU = 1.6 (P = 3.50 × 10−22) for ISPD; (F) fold change between WHMT and HIPP = 1.1 (P = 5.00 × 10−8) for AGR2. CRBL = cerebellar cortex; FCTX = frontal cortex; HIPP = hippocampus; MEDU = medulla; OCTX = occipital cortex; PUTM = putamen; SNIG = substantia nigra; TCTX = temporal cortex; THAL = thalamus; WHMT = intralobular white matter.
See this image and copyright information in PMC

Comment in

Comment on

  • Sex differences in the genetic predictors of Alzheimer's pathology.
    Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Bush WS, Gifford KA, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Deming Y, Chao MJ, Huentelman M, Martin ER, Hamilton-Nelson K, Shaw LM, Trojanowski JQ, Peskind ER, Cruchaga C, Pericak-Vance MA, Goate AM, Cox NJ, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M; Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative; Bennett DA, Schneider JA, Jefferson AL, Hohman TJ. Dumitrescu L, et al. Brain. 2019 Sep 1;142(9):2581-2589. doi: 10.1093/brain/awz206. Brain. 2019. PMID: 31497858 Free PMC article.

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