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Review
. 2020 Dec;198(6):897-907.
doi: 10.1007/s00408-020-00407-5. Epub 2020 Nov 11.

Update 2020: Management of Non-Small Cell Lung Cancer

Mariam Alexander  1 , So Yeon Kim  2 , Haiying Cheng  3
Affiliations
Review

Update 2020: Management of Non-Small Cell Lung Cancer

Mariam Alexander et al. Lung. 2020 Dec.

Abstract

The past decade has seen a revolution of new advances in the management of non-small cell lung cancer (NSCLC) with remarkable progresses in screening, diagnosis, and treatment. The advances in systemic treatment have been driven primarily by the development of molecularly targeted therapeutics, immune checkpoint inhibitors, and anti-angiogenic agents, all of which have transformed this field with significantly improved patient outcomes. This review will address updates in lung cancer screening, liquid biopsy, and immunotherapy in the front-line setting. We discuss recent advances and highlight the plethora of new approvals of molecular-targeted therapy for subgroups of NSCLC patients with sensitizing EGFR, ALK, ROS1, RET, BRAF V600E, MET, and NTRK alterations.

Keywords: Immune checkpoint inhibitors; Lung cancer; Targeted therapy.

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Conflict of interest statement

Mariam Alexander and So Yeon Kim do not have any conflicts of interest to disclose. Haiying Cheng has received research funding from Genentech/Roche, Eisai, Spectrum, Regeneron, Bayer, and Vaccinex.

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