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. 2020 Nov 12;13(11):CIRCHEARTFAILURE120007636.
doi: 10.1161/CIRCHEARTFAILURE.120.007636. Online ahead of print.

Virus-Negative Myopericarditis in Human Coronavirus Infection: Report From an Autopsy Series

Franca Del Nonno #  1   2   3   4   5 , Andrea Frustaci #  1   2   3   4   5 , Romina Verardo  1   2   3   4   5 , Cristina Chimenti  1   2   3   4   5 , Emanuele Nicastri  1   2   3   4   5 , Andrea Antinori  1   2   3   4   5 , Nicola Petrosillo  1   2   3   4   5 , Eleonora Lalle  1   2   3   4   5 , Chiara Agrati  1   2   3   4   5 , Giuseppe Ippolito  1   2   3   4   5 ; INMI COVID study group  1   2   3   4   5
Affiliations

Virus-Negative Myopericarditis in Human Coronavirus Infection: Report From an Autopsy Series

Franca Del Nonno et al. Circ Heart Fail. .

Abstract

Supplemental Digital Content is available in the text.

Keywords: autopsy; coronavirus infections; heart failure; hypertension; stroke volume.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure 1.
Figure 1.
Cardiac postmortem findings in 9 patients affected by coronavirus disease 2019 (COVID-19) infection. A, Overweight heart (450 g) in a patient with coronavirus infection. Plaque-like fibrous whitish thickened pericardium denoting pericarditis. B, Grossly, the heart was dilated, and the ventricular myocardium was flabby and pale with thickened walls. C, Lymphocytic myocarditis (hematoxlin and eosin, 200×). D, Immunohistochemistry for cluster differentiation68 showing positive macrophages in the inflamed myocardium. E and F, Lymphocytic pericarditis (hematoxlin and eosin, 200×). G, Necrotizing vasculitis of an intramural coronary artery (hematoxlin and eosin, 200×). H, Immunohistochemistry for Cluster differentiation45Ro suggesting lymphocytic infiltration and necrosis of an intramural coronary artery (200×). I, Lymphocytic infiltration of a subepicardial ganglion (cluster differentiation45Ro, 400×). J, Severe infiltration with damage of a section of conduction tissue (hematoxlin and eosin, 200×).
Figure 2.
Figure 2.
Biomarker data of 9 patients (pts) with coronavirus infection. The levels of fibrinogen, CRP, d-dimer, lactate dehydrogenase (LDH), troponin I, and lymphocytes were evaluated by diagnostic tools in 9 pts with coronavirus infection. CRP indicates C-reactive protein; and na, not available.
See this image and copyright information in PMC

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