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Multicenter Study
. 2021 Apr 7;16(4):648-659.
doi: 10.2215/CJN.07830520. Epub 2020 Nov 11.

Risk Factors for CKD Progression: Overview of Findings from the CRIC Study

Mary Hannan  1 , Sajid Ansari  1 , Natalie Meza  1 , Amanda H Anderson  2 , Anand Srivastava  3 , Sushrut Waikar  4 , Jeanne Charleston  5 , Matthew R Weir  6 , Jonathan Taliercio  7 , Edward Horwitz  8 , Milda R Saunders  9 , Katherine Wolfrum  10 , Harold I Feldman  11   12 , James P Lash  1 , Ana C Ricardo  1 ; CRIC Study Investigators; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
Collaborators, Affiliations
Multicenter Study

Risk Factors for CKD Progression: Overview of Findings from the CRIC Study

Mary Hannan et al. Clin J Am Soc Nephrol. .

Abstract

The Chronic Renal Insufficiency Cohort (CRIC) Study is an ongoing, multicenter, longitudinal study of nearly 5500 adults with CKD in the United States. Over the past 10 years, the CRIC Study has made significant contributions to the understanding of factors associated with CKD progression. This review summarizes findings from longitudinal studies evaluating risk factors associated with CKD progression in the CRIC Study, grouped into the following six thematic categories: (1) sociodemographic and economic (sex, race/ethnicity, and nephrology care); (2) behavioral (healthy lifestyle, diet, and sleep); (3) genetic (apoL1, genome-wide association study, and renin-angiotensin-aldosterone system pathway genes); (4) cardiovascular (atrial fibrillation, hypertension, and vascular stiffness); (5) metabolic (fibroblast growth factor 23 and urinary oxalate); and (6) novel factors (AKI and biomarkers of kidney injury). Additionally, we highlight areas where future research is needed, and opportunities for interdisciplinary collaboration.

Keywords: chronic kidney disease; progression of chronic renal failure; risk factors.

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Figures

Figure 1.
Figure 1.
Phases of the Chronic Renal Insufficiency Cohort (CRIC) Study.
Figure 2.
Figure 2.
Theoretic model: Interaction of biologic and clinical factors with the social determinants of health affecting CKD progression. Biologic and clinical factors likely interact with the social determinants of health at several levels to increase risk of CKD progression. Adapted from ref. , with permission.
See this image and copyright information in PMC

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