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. 2020 Nov 11;10(11):e038119.
doi: 10.1136/bmjopen-2020-038119.

Cohort profile: The Forzani & MacPhail Colon Cancer Screening Centre biorepository, Calgary, Alberta

Robert J Hilsden  1 , Steven J Heitman  2 , Mubasiru Lamidi  2 , Mamadou Dian Diallo  2 , Janine English  2 , Susanna Town  2 , Shane Cartwright  2 , Courtney Maxwell  2 , Mary-Elizabeth McGillivray  2 , Elizabeth McGregor  2 , Amanda Barberio  3 , Joy Pader  3 , Darren Brenner  3   4   5 , Linda Rabeneck  6
Affiliations

Cohort profile: The Forzani & MacPhail Colon Cancer Screening Centre biorepository, Calgary, Alberta

Robert J Hilsden et al. BMJ Open. .

Abstract

Purpose: The Colon Cancer Screening Centre (CCSC) biorepository (Calgary, Canada) supports a wide range of research topics related to colorectal cancer (CRC) by collecting, and storing biospecimens (blood, urine, normal colon tissue) from consenting patient participants. Housing unique biospecimens along with detailed participant lifestyle and health history questionnaire data, the CCSC biorepository can support a variety of research related to CRC risk factors, biomarkers, genetic causes and more.

Participants: Currently, 2292 average risk CRC patients have consented to participate in the CCSC cohort and have provided stored biospecimens. The collected samples and data provide important high-quality materials for research, discovery and evaluation related to CRC screening and carcinogenesis and is available for access by outside researchers. In addition to biological samples, the CCSC collects detailed patient information on their lifestyle, physical activity and dietary patterns through questionnaires at the time of their enrolment.

Findings to date: The majority of participants (75%) are between 50 and 64 years of age. Women make up 46% (1055) of the cohort. Additional characteristics of the cohort included 44% reporting a body mass index of 25-30 kg/m2 (overweight), 53% having never smoked tobacco and 13% having a family member with CRC.

Future plans: The CCSC cohort plans to include the recruitment of high risk CRC cohorts. High-risk participants would comprise patients with a positive faecal immunochemical test and family history of CRC.

Keywords: gastroenterology; gastrointestinal tumours; oncology.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Overview of the CCSC Biorepository recruitment and data collection process. CCSC, Colon Cancer Screening Centre; FMCCSC, Forzani & MacPhail Colon Cancer Screening Centre.
See this image and copyright information in PMC

References

    1. Canadian Cancer Society Canadian cancer society’s advisory committee on cancer statistics: Canadian cancer statistics 2017 [PDF]. Canadian cancer society, statistics Canada, public health agency of Canada, provincial/territorial cancer registries. Available: www.cancer.ca/Canadian-Cancer-Statistics-2017-EN [Accessed 10 Jul 2018].
    1. Safiri S, Sepanlou SG, Ikuta KS, et al. . The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the global burden of disease study 2017. Lancet Gastroenterol Hepatol 2019;4:913–33. 10.1016/S2468-1253(19)30345-0 - DOI - PMC - PubMed
    1. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759–67. 10.1016/0092-8674(90)90186-I - DOI - PubMed
    1. Jasperson KW, Tuohy TM, Neklason DW, et al. . Hereditary and familial colon cancer. Gastroenterology 2010;138:2044–58. 10.1053/j.gastro.2010.01.054 - DOI - PMC - PubMed
    1. Ma Y, Yang Y, Wang F, et al. . Obesity and risk of colorectal cancer: a systematic review of prospective studies. PLoS One 2013;8:e53916 10.1371/journal.pone.0053916 - DOI - PMC - PubMed

Publication types

Grants and funding