Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Oct 15:11:642.
doi: 10.3389/fendo.2020.00642. eCollection 2020.

Homozygosity in the APOE 3 Polymorphism Is Associated With Less Depression and Higher Serum Low-Density Lipoprotein in Chinese Elderly Schizophrenics

Wei Li  1   2 , Chunxia Ban  3 , Ling Yue  1   2 , Lin Sun  1   2 , Xia Li  1   2 , Shifu Xiao  1   2
Affiliations

Homozygosity in the APOE 3 Polymorphism Is Associated With Less Depression and Higher Serum Low-Density Lipoprotein in Chinese Elderly Schizophrenics

Wei Li et al. Front Endocrinol (Lausanne). .

Abstract

Background: Depressive symptoms are common comorbidities in schizophrenia. However, the effect of APOE E3 on depressive symptoms has never been investigated in an aging Chinese population with schizophrenia. This cross-sectional study aimed to investigate the effects of APOE E3 on blood lipid metabolism and depressive symptoms in elderly schizophrenics in China. Methods: Three Hundred and one elderly schizophrenics (161 males, age ranges from 60 to 92 years, with an average age of 67.31 ± 6.667) were included in the study. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS). APOE gene polymorphism was determined by polymerase chain reaction (PCR). We assessed the correlations of GDS and serum low-density lipoprotein (LDL) with APOE genotypes. Results: The concentration of LDL in the Homozygous APOE E3 group was significantly higher than that in the non-homozygous APOE E3 group, while the scores of GDS of the Homozygous APOE E3 group were lower than that in the non-homozygous APOE E3 group. Using partial correlation analysis and controlling age, gender, duration of disease, and hyperlipidemia, we found that the scores of GDS were significantly correlated with LDL (r = -0.194, p = 0.016). Conclusions: APOE E3 is associated with less depressive symptoms and higher serum LDL in Chinese elderly patients with schizophrenia, and there is a negative correlation between depressive symptoms and LDL.

Keywords: APOE E3; Chinese; aging; depressive symptom; schizophrenia.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Comparsion of LDL between two groups. *means p < 0.05.
Figure 2
Figure 2
Comparsion of GDS between two groups. *means p < 0.05.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Felmet K, Zisook S, Kasckow JW. Elderly patients with schizophrenia and depression: diagnosis and treatment. Clin. Schizophr. Relat. Psychoses. (2011) 4:239–50. 10.3371/CSRP.4.4.4 - DOI - PMC - PubMed
    1. Xu YM, Li F, Liu XB, Zhong BL. Depressive symptoms in Chinese male inpatients with schizophrenia: prevalence and clinical correlates. Psychiatry Res. (2018) 264:380–84. 10.1016/j.psychres.2018.04.016 - DOI - PubMed
    1. Baynes D, Mulholland C, Cooper SJ, Montgomery RC, MacFlynn G, Lynch G, et al. . Depressive symptoms in stable chronic schizophrenia: prevalence and relationship to psychopathology and treatment. Schizophr. Res. (2000) 45:47–56. 10.1016/S0920-9964(99)00205-4 - DOI - PubMed
    1. Peitl V, Vidrih B, Karlovic Z, Getaldic B, Peitl M, Karlovic D. Platelet serotonin concentration and depressive symptoms in patients with schizophrenia. Psychiatry Res. (2016) 239:105–10. 10.1016/j.psychres.2016.03.006 - DOI - PubMed
    1. Majadas S, Olivares J, Galan J, Diez T. Prevalence of depression and its relationship with other clinical characteristics in a sample of patients with stable schizophrenia. Compr. Psychiatry. (2012) 53:145–51. 10.1016/j.comppsych.2011.03.009 - DOI - PubMed

Publication types