Review
doi: 10.1126/science.3317825.
Development of the primary antibody repertoire
Affiliations
- PMID: 3317825
- DOI: 10.1126/science.3317825
Item in Clipboard
Review
Development of the primary antibody repertoire
Science.
.
Abstract
The ability to generate a diverse immune response depends on the somatic assembly of genes that encode the antigen-binding portions of immunoglobulin molecules. In this article, we discuss the mechanism and control of these genomic rearrangement events and how aspects of this process are involved in generating the primary antibody repertoire.
Similar articles
-
Evolutionary and somatic selection of the antibody repertoire in the mouse.Science. 1987 Nov 20;238(4830):1088-94. doi: 10.1126/science.3317826. Science. 1987. PMID: 3317826 Review.
-
Development of the antibody repertoire in rabbit: gut-associated lymphoid tissue, microbes, and selection.Immunol Rev. 2000 Jun;175:214-28. Immunol Rev. 2000. PMID: 10933605 Review.
-
The imprint of somatic hypermutation on the repertoire of human germline V genes.J Mol Biol. 1996 Mar 15;256(5):813-17. doi: 10.1006/jmbi.1996.0127. J Mol Biol. 1996. PMID: 8601832
-
Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte.J Exp Med. 1989 Oct 1;170(4):1211-30. doi: 10.1084/jem.170.4.1211. J Exp Med. 1989. PMID: 2507726 Free PMC article.
-
The human antibody repertoire to infectious agents: implications for disease pathogenesis.Mol Immunol. 2003 Sep;40(1):1-11. doi: 10.1016/s0161-5890(03)00099-3. Mol Immunol. 2003. PMID: 12909126 Review.
Cited by
-
Sequencing the functional antibody repertoire--diagnostic and therapeutic discovery.Nat Rev Rheumatol. 2015 Mar;11(3):171-82. doi: 10.1038/nrrheum.2014.220. Epub 2014 Dec 23. Nat Rev Rheumatol. 2015. PMID: 25536486 Free PMC article. Review.
-
Gene Conversion-Like Events in the Diversification of Human Rearranged IGHV3-23*01 Gene Sequences.Front Immunol. 2012 Jun 15;3:158. doi: 10.3389/fimmu.2012.00158. eCollection 2012. Front Immunol. 2012. PMID: 22715339 Free PMC article.
-
CDR-H3 diversity is not required for antigen recognition by synthetic antibodies.J Mol Biol. 2013 Feb 22;425(4):803-11. doi: 10.1016/j.jmb.2012.11.037. Epub 2012 Dec 3. J Mol Biol. 2013. PMID: 23219464 Free PMC article.
-
Corrective recombination of mouse immunoglobulin kappa alleles in Abelson murine leukemia virus-transformed pre-B cells.Mol Cell Biol. 1990 Feb;10(2):569-76. doi: 10.1128/mcb.10.2.569-576.1990. Mol Cell Biol. 1990. PMID: 2153918 Free PMC article.
-
A recombinase from Drosophila melanogaster embryos.Proc Natl Acad Sci U S A. 1988 Oct;85(20):7481-5. doi: 10.1073/pnas.85.20.7481. Proc Natl Acad Sci U S A. 1988. PMID: 3140242 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
