Review
doi: 10.1126/science.3317828.
Redesigning nature's poisons to create anti-tumor reagents
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- PMID: 3317828
- DOI: 10.1126/science.3317828
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Review
Redesigning nature's poisons to create anti-tumor reagents
Science.
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Abstract
Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.
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