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Review
. 2020 Oct 15:8:573455.
doi: 10.3389/fcell.2020.573455. eCollection 2020.

Yes-Associated Protein 1: Role and Treatment Prospects in Orthopedic Degenerative Diseases

Wenqing Xie  1   2 , Wenfeng Xiao  1   2 , Kun Tang  3 , Liyang Zhang  4 , Yusheng Li  1   2
Affiliations
Review

Yes-Associated Protein 1: Role and Treatment Prospects in Orthopedic Degenerative Diseases

Wenqing Xie et al. Front Cell Dev Biol. .

Abstract

The Hippo/yes-associated protein 1 signaling pathway is an evolutionarily conserved signaling pathway. This signaling pathway is primarily involved in the regulation of stem cell self-renewal, organ size and tissue regeneration by regulating cell proliferation, differentiation and apoptosis. It plays an important role in embryonic development and tissue organ formation. Yes-associated protein 1 (YAP1) is a key transcription factor in the Hippo signaling pathway and is negatively regulated by this pathway. Changes in YAP1 expression levels affect the occurrence and development of a variety of tumors, but the specific mechanism associated with this phenomenon has not been thoroughly studied. Recently, several studies have described the role of YAP1 in osteoarthritis (OA). Indeed, YAP1 is involved in orthopedic degenerative diseases such as osteoporosis (OP) in addition to OA. In this review, we will summarize the significance of YAP1 in orthopedic degenerative diseases and discuss the potential of the targeted modulation of YAP1 for the treatment of these diseases.

Keywords: chondrocyte; mesenchymal stem cells; osteoarthritis; osteoporosis; yes-associated protein 1.

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Figures

FIGURE 1
FIGURE 1
Modular structure of YAP1 protein.
FIGURE 2
FIGURE 2
The specific signaling pathways of YAP1 promoting the occurrence and development of OA.
FIGURE 3
FIGURE 3
The regulatory role of YAP1/TAZ in the osteogenic and adipogenic differentiation of MSCs.
FIGURE 4
FIGURE 4
The effects of Piezo1 mediated mechanical stimulation in OB and OC.
See this image and copyright information in PMC

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