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. 2020 Oct 14:7:580677.
doi: 10.3389/fmed.2020.580677. eCollection 2020.

Frequencies of CD33+CD11b+HLA-DR-CD14-CD66b+ and CD33+CD11b+HLA-DR-CD14+CD66b- Cells in Peripheral Blood as Severity Immune Biomarkers in COVID-19

Ricardo Wesley Alberca  1 , Milena Mary de Souza Andrade  1 , Anna Cláudia Calvielli Castelo Branco  1   2 , Anna Julia Pietrobon  1   2 , Nátalli Zanete Pereira  1 , Iara Grigoletto Fernandes  1 , Luana de Mendonça Oliveira  1   2 , Franciane Mouradian Emidio Teixeira  1   2 , Danielle Rosa Beserra  1 , Emily Araujo de Oliveira  1 , Sarah Cristina Gozzi-Silva  2 , Yasmim Álefe Leuzzi Ramos  1 , Cyro Alves de Brito  3 , Marcelo Arnone  4 , Raquel Leao Orfali  1 , Valeria Aoki  1 , Alberto Jose da Silva Duarte  5 , Maria Notomi Sato  1
Affiliations

Frequencies of CD33+CD11b+HLA-DR-CD14-CD66b+ and CD33+CD11b+HLA-DR-CD14+CD66b- Cells in Peripheral Blood as Severity Immune Biomarkers in COVID-19

Ricardo Wesley Alberca et al. Front Med (Lausanne). .

Abstract

Common clinical features of patients with Coronavirus disease-2019 (COVID-19) vary from fever, to acute severe respiratory distress syndrome. Several laboratory parameters are reported as indicators of COVID-19 severity. We hereby describe the possible novel severity biomarkers for COVID-19, CD11b+CD33+HLA-DR-CD14+ cells and CD11b+CD33+HLA-DR-CD66b+ cells.

Keywords: COVID-19; SARS-CoV-2; biomarker; infection; severity.

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Figures

Figure 1
Figure 1
Frequencies of CD11b+CD33+HLA-DR-CD14+ cells or CD11b+CD33+HLA-DR-CD66b cells in peripheral blood of HC, GW, and ICU COVID-19 patients. (A) Gate strategy used for flow cytometry: single cells, live, CD11b+CD33+HLA-DR-CD14+ or CD66b+; (B) Representative plots for HC, GW, and ICU; (C) Frequency of CD11b+CD33+HLA-DR-CD14+ and (D) CD11b+CD33+HLA-DR-CD66b in the peripheral blood of HC, GW, and ICU. Kruskal-Wallis test with Dunn's post-test. *p < 0.05, ****p < 0.0001.
See this image and copyright information in PMC

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