Structural aberrations are associated with poor survival in patients with clonal cytopenia of undetermined significance

Abstract

Not available.

Figure 1.

Single nucleotide polymorphism- based array analysisdetected structural aberrations demarcate survival in patients with idiopathic cytopenia of undetermined significance but are not an independent adverse prognostic factor. Kaplan-Meier estimates of (A) overall survival and (B) progression- free survival of the group of idiopathic cytopenia of undetermined significance (ICUS) patients with copy number aberrations (CNA) or copy neutral loss of heterozygosity (CNLOH) (excluding loss of the Y chromosome; red curve) and the group of ICUS patients without CNA or CNLOH (black curve). (C) Forest plot of hazard ratios (HR) including 95% Confidence intervals (CI) for allcause mortality in multivariable analysis in ICUS patients (n=109 with complete data). Overall survival was measured from first bone marrow investigation (=inclusion) to death from any cause. Progression-free survival was measured from first bone marrow investigation to progression to a myeloid cancer or death from any cause. Annotated P-values are from two-sided log-rank tests. Severe anemia was defined as hemoglobin <100 g/L. Mutations were identified by targeted next generation sequencing using a 20- gene panel with a lower limit of detection at 2%.

Figure 2.

In patienst with clonal cytopenia of undetermined significance, the presence of additional structural aberrations is associated with an increased hazard of all-cause mortality in univariable and multivariable analysis. (A) Kaplan-Meier estimates of overall survival of the group of clonal cytopenia of undetermined significance (CCUS) patients with copy number aberrations (CNA) or copy neutral loss of heterozygosity (CNLOH) (excluding loss of the Y chromosome; red curve) and the group of CCUS patients without CNA or CNLOH (black curve). (B) Forest plot of hazard ratios (HR) including 95% Confidence Intervals (CI) for all-cause mortality in multivariable analysis in CCUS patients (n=51 with complete data). Overall survival was measured from first bone marrow investigation (=inclusion) to death from any cause. Patients alive at the last date of follow-up were censored at that time. Annotated P-values are from two-sided log-rank tests. Severe anemia was defined as hemoglobin <100 g/L.