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Comment
. 2021 Jan 21;117(2):e26-e28.
doi: 10.1093/cvr/cvaa309.

Sleep deficiency and mortality: is the solution in the gut?

Yasuki Nakada  1 , Junichi Sadoshima  1
Affiliations
Comment

Sleep deficiency and mortality: is the solution in the gut?

Yasuki Nakada et al. Cardiovasc Res. .
No abstract available

Keywords: Antioxidant; Cardiovascular disease; Intestines; Oxidative stress; Sleep deficiency.

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Figures

Figure 1
Figure 1
A hypothetical representation of how sleep deprivation affects cellular responses in intestinal epithelial cells, and the potential contribution of oxidative stress in the gut to premature death in flies and cardiovascular conditions in humans. Sleep deprivation induces oxidative stress in intestinal epithelial cells through either increased production or reduced scavenging of ROS. Inhibition of oxidative stress in the gut alleviates the premature death of flies even in the presence of severe sleep deprivation. Whether or not suppression of oxidative stress in the gut also reduces cardiovascular complications induced by sleep deprivation remains to be shown. ATP, adenosine triphosphate; CAD, coronary artery disease; DM, diabetes mellitus.
None
None
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