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. 2021 Mar 1;60(10):5220-5224.
doi: 10.1002/anie.202012124. Epub 2021 Jan 12.

A Photoregulated Racemase Mimic

Monochura Saha  1 , Munshi Sahid Hossain  1 , Subhajit Bandyopadhyay  1
Affiliations

A Photoregulated Racemase Mimic

Monochura Saha et al. Angew Chem Int Ed Engl. .

Abstract

The racemase enzymes convert L-amino acids to their D-isomer. The reaction proceeds through a stepwise deprotonation-reprotonation mechanism that is assisted by a pyridoxal phosphate (PLP) coenzyme. This work reports a PLP-photoswitch-imidazole triad where the racemization reaction can be controlled by light by tweaking the distance between the basic residue and the reaction centre.

Keywords: azobenzene; biomimetic; photochemistry; photochromism; racemase.

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