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. 2020 Nov 12;15(11):e0241556.
doi: 10.1371/journal.pone.0241556. eCollection 2020.

Sex disparities in dialysis initiation, access to waitlist, transplantation and transplant outcome in German patients with renal disease-A population based analysis

Anette Melk  1 , Bernhard M W Schmidt  2 , Siegfried Geyer  3 , Jelena Epping  3
Affiliations

Sex disparities in dialysis initiation, access to waitlist, transplantation and transplant outcome in German patients with renal disease-A population based analysis

Anette Melk et al. PLoS One. .

Abstract

Background: Renal transplantation access and outcome differ between men and women, but no analysis has considered all transition phases and transplant outcome using the same data set. We analyzed sex disparities in all phases of patients' clinical path (progression to dialysis, waitlisting, transplantation, graft failure/death).

Methods: In a population based approach using health insurance data (2005-2013) we examined patients' risk of changing from one phase to another applying Cox Proportional Hazards model.

Results: After adjusting for age and comorbidities, women had a 16% lower risk of progression to ESRD (HR/95%-CI: 0.84/0.79-0.88). Access to the waitlist was lowered by 18% in women compared to men (HR/95%-CI: 0.82/0.70-0.96). An age stratified analysis did not reveal differences in any age group. Once waitlisted, the chance to receive a transplant was identical (HR/95%-CI: 0.96/0.81-1.15). The risk of transplant failure/death was identical for both sexes (HR/95%-CI: 0.99/0.73-1.35), but the effect was modified by age: in younger women (18-45 years) the risk was twice as high compared to men (HR/95%-CI: 2.08/1.04-4.14), whereas the risk in elderly women (> 65 years) was only half the risk of men (HR/95%-CI: 0.47/0.24-0.93).

Conclusion: Sex disparities occurred at different steps in the history of patients with renal disease and affected progression to dialysis, waitlisting and transplantation outcome in a population with equal access to medical treatment.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Number of patients in the respective subpopulations used for the analysis.
Fig 2
Fig 2. Waitlist access.
Cumulative incidence curve of being waitlisted after entering dialysis treatment.
Fig 3
Fig 3. Waitlist access by age group.
Hazard ratios (HRs) for the unadjusted (unadj.) model and the model adjusted (adj.) for age and comorbidities.
Fig 4
Fig 4. Risk of transplant failure or death.
See this image and copyright information in PMC

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