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. 2020 Nov 12;16(11):e1008983.
doi: 10.1371/journal.ppat.1008983. eCollection 2020 Nov.

Harnessing early life immunity to develop a pediatric HIV vaccine that can protect through adolescence

Ria Goswami  1 , Stella J Berendam  1 , Shuk Hang Li  1 , Ashley N Nelson  1 , Kristina De Paris  2   3 , Koen K A Van Rompay  4 , Sallie R Permar  1   5 , Genevieve G Fouda  1   5
Affiliations

Harnessing early life immunity to develop a pediatric HIV vaccine that can protect through adolescence

Ria Goswami et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Early life vaccination to achieve protection from bimodal HIV acquisition.
An HIV vaccine administered at birth with successive boosting during infancy will induce anti-HIV neutralizing and non-neutralizing antibody responses and HIV-specific cellular immunity that will reduce the risk of HIV infection via breastfeeding. Moreover, immunization started at birth and boosted during infancy, childhood and preadolescence will provide those neutralizing antibodies sufficient time to mature, undergo extensive affinity maturation, and SHM and enhance their breadth and strength prior to sexual debut. These developed bNabs will confer protection against sexual transmission of HIV during adulthood. bNabs, broadly neutralizing antibodies; SHM, somatic hypermutation.
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