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. 2020 Nov 12;16(11):e1008930.
doi: 10.1371/journal.ppat.1008930. eCollection 2020 Nov.

Insights into malaria pathogenesis gained from host metabolomics

Heather N Colvin  1   2 , Regina Joice Cordy  1   2
Affiliations

Insights into malaria pathogenesis gained from host metabolomics

Heather N Colvin et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Examples of metabolic pathways perturbed in the host during acute malaria.
Biochemical pathways of amino acids (yellow), lipids (purple), and heme (green) found to be either increased (red) or decreased (blue) in acute malaria as compared to healthy individuals. (A) Amino acids involved in the de novo biosynthesis of arginine are globally decreased during malaria [9,18,21]. Metabolic changes associated with malaria also include (B) elevated conversion of tryptophan to kynurenine via IDO enzyme [9,11,20,28], (C) depleted LPC from phospholipids [9,11,32], and (D) increased heme products indicating hemolysis and hemoglobin degradation [–11]. (E) Lysine catabolism into pipecolic acid is also detected in Plasmodium infections [–35]. IDO, indoleamine 2,3-dioxygenase; LPC, lysophosphatidylcholine.
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