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Comment
. 2020 Nov 11;108(3):397-399.
doi: 10.1016/j.neuron.2020.10.018.

Microglia Tweak Retinogeniculate Pathways during Visual Circuit Refinement

Tara Keck  1
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Microglia Tweak Retinogeniculate Pathways during Visual Circuit Refinement

Tara Keck. Neuron. .
Free article

Abstract

Cheadle et al. reveal that microglia expressing TWEAK facilitate synapse elimination through a novel, non-phagocytic mechanism in the retinogeniculate pathway during visual circuit development. This mechanism is experience-dependent and occurs through the local binding of TWEAK to postsynaptic Fn14.

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