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. 2021 Feb:103:617-623.
doi: 10.1016/j.ijid.2020.11.005. Epub 2020 Nov 9.

The time-varying transmission dynamics of COVID-19 and synchronous public health interventions in China

Jianpeng Xiao  1 , Jianxiong Hu  1 , Guanhao He  1 , Tao Liu  1 , Min Kang  2 , Zuhua Rong  1 , Lifeng Lin  2 , Haojie Zhong  2 , Qiong Huang  2 , Aiping Deng  2 , Weilin Zeng  1 , Xiaohua Tan  2 , Siqing Zeng  1 , Zhihua Zhu  1 , Jiansen Li  2 , Dexin Gong  1 , Donghua Wan  1 , Shaowei Chen  1 , Lingchuan Guo  1 , Yihan Li  1 , Yan Li  2 , Limei Sun  2 , Wenjia Liang  2 , Tie Song  2 , Jianfeng He  3 , Wenjun Ma  4
Affiliations

The time-varying transmission dynamics of COVID-19 and synchronous public health interventions in China

Jianpeng Xiao et al. Int J Infect Dis. 2021 Feb.

Abstract

Objectives: We aimed to estimate the time-varying transmission dynamics of COVID-19 in China, Wuhan City, and Guangdong province, and compare to that of severe acute respiratory syndrome (SARS).

Methods: Data on COVID-19 cases in China up to 20 March 2020 was collected from epidemiological investigations or official websites. Data on SARS cases in Guangdong Province, Beijing, and Hong Kong during 2002-3 was also obtained. We estimated the doubling time, basic reproduction number (R0), and time-varying reproduction number (Rt) of COVID-19 and SARS.

Results: As of 20 March 2020, 80,739 locally acquired COVID-19 cases were identified in mainland China, with most cases reported between 20 January and 29 February 2020. The R0 value of COVID-19 in China and Wuhan was 5.0 and 4.8, respectively, which was greater than the R0 value of SARS in Guangdong (R0 = 2.3), Hong Kong (R0 = 2.3), and Beijing (R0 = 2.6). At the start of the COVID-19 epidemic, the Rt value in China peaked at 8.4 and then declined quickly to below 1.0 in one month. With SARS, the Rt curve saw fluctuations with more than one peak, the highest peak was lower than that for COVID-19.

Conclusions: COVID-19 has much higher transmissibility than SARS, however, a series of prevention and control interventions to suppress the outbreak were effective. Sustained efforts are needed to prevent the rebound of the epidemic in the context of the global pandemic.

Keywords: COVID-19; China; SARS; Time-varying reproduction number.

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Figures

Figure 1
Figure 1
Distribution of COVID-19 cases in China, as of March 20, 2020.
Figure 2
Figure 2
Temporal distribution of confirmed COVID-19 cases in China, Wuhan, and Guangdong Province. Panel A: Temporal distribution of COVID-19 cases in China; Panel B: Temporal distribution of COVID-19 cases in Wuhan; Panel C: Temporal distribution of all confirmed COVID-19 cases in Guangdong Province; Panel D: Temporal distribution of secondary COVID-19 cases in Guangdong Province.
Figure 3
Figure 3
Time-varying reproduction number (Rt) of COVID-19 and SARS in China. Panel A: Rt of COVID-19 nationwide; Panel B: Rt of COVID-19 in Wuhan; Panel C: Rt of secondary COVID-19 in Guangdong Province; Panel D: Rt of SARS in Guangdong Province; Panel E: Rt of SARS in Hong Kong; Panel F: Rt of SARS in Beijing.
Figure 4
Figure 4
The epidemic curve, key events, and public health interventions in mainland China.
See this image and copyright information in PMC

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