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Review
. 2020 Nov 9;21(21):8390.
doi: 10.3390/ijms21218390.

Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopecia

Antonio Martinez-Lopez  1   2 , Trinidad Montero-Vilchez  1 , Álvaro Sierra-Sánchez  3   4 , Alejandro Molina-Leyva  1   2 , Salvador Arias-Santiago  1   2   3   4   5
Affiliations
Review

Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopecia

Antonio Martinez-Lopez et al. Int J Mol Sci. .

Abstract

Alopecia is a challenging condition for both physicians and patients. Several topical, intralesional, oral, and surgical treatments have been developed in recent decades, but some of those therapies only provide partial improvement. Advanced medical therapies are medical products based on genes, cells, and/or tissue engineering products that have properties in regenerating, repairing, or replacing human tissue. In recent years, numerous applications have been described for advanced medical therapies. With this background, those therapies may have a role in the treatment of various types of alopecia such as alopecia areata and androgenic alopecia. The aim of this review is to provide dermatologists an overview of the different advanced medical therapies that have been applied in the treatment of alopecia, by reviewing clinical and basic research studies as well as ongoing clinical trials.

Keywords: advanced medical therapies; alopecia areata; androgenic alopecia; gene therapy; mesenchymal stem cells; tissue engineering.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Advanced therapies and their use in alopecia: cell therapy, gene therapy, and tissue engineering therapy. Created with Biorender.com.
Figure 2
Figure 2
Procurement and production of mesenchymal stem cells. Created with Biorender.com.
See this image and copyright information in PMC

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