Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Nov 10;10(11):1536.
doi: 10.3390/biom10111536.

Curcumin against Prostate Cancer: Current Evidence

Deborah Termini  1 , Danja J Den Hartogh  1   2 , Alina Jaglanian  1 , Evangelia Tsiani  1   2
Affiliations
Review

Curcumin against Prostate Cancer: Current Evidence

Deborah Termini et al. Biomolecules. .

Abstract

Cancer is a condition characterized by remarkably enhanced rates of cell proliferation paired with evasion of cell death. These deregulated cellular processes take place following genetic mutations leading to the activation of oncogenes, the loss of tumor suppressor genes, and the disruption of key signaling pathways that control and promote homeostasis. Plant extracts and plant-derived compounds have historically been utilized as medicinal remedies in different cultures due to their anti-inflammatory, antioxidant, and antimicrobial properties. Many chemotherapeutic agents used in the treatment of cancer are derived from plants, and the scientific interest in discovering plant-derived chemicals with anticancer potential continues today. Curcumin, a turmeric-derived polyphenol, has been reported to possess antiproliferative and proapoptotic properties. In the present review, we summarize all the in vitro and in vivo studies examining the effects of curcumin in prostate cancer.

Keywords: androgen-insensitive; androgen-sensitive; apoptosis; curcumin; in vitro; in vivo; polyphenol; proliferation; prostate cancer; survival.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Prostate cancer subtypes and the respective best treatment strategy available.
Figure 2
Figure 2
Chemical structure of (A) curcumin, (B) bisdemethoxycurcumin, and (C) demethoxycurcumin.
Figure 3
Figure 3
Effects of curcumin treatment on prostate cancer cells in vitro. The figure is based on the data of the studies [54,55,56,57,58,59,60,61,62,63,64,65,66,67,68] and created using BioRender.com.
Figure 4
Figure 4
Effects of curcumin administration to animals xenografted with prostate cancer cells. The figure was created based on data from the studies [85,86,88,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117] and created using BioRender.com.
See this image and copyright information in PMC

References

    1. Lodish H., Berk A., Zipursky S.L., Matsudaira P., Baltimore D., Darnell J. Molecular Cell Biology. 4th ed. W. H. Freeman and Company; New York, NY, USA: 2000. Proto-Oncogenes and Tumor-Suppressor Genes.
    1. Hanahan D., Weinberg R.A. Hallmarks of cancer: The next generation. Cell. 2011;144:646–674. doi: 10.1016/j.cell.2011.02.013. - DOI - PubMed
    1. Sarkar S., Horn G., Moulton K., Oza A., Byler S., Kokolus S., Longacre M. Cancer Development, Progression, and Therapy: An Epigenetic Overview. Int. J. Mol. Sci. 2013;14:21087–21113. doi: 10.3390/ijms141021087. - DOI - PMC - PubMed
    1. Mattiuzzi C., Lippi G. Current Cancer Epidemiology. J. Epidemiol. Glob. Health. 2019;9:217–222. doi: 10.2991/jegh.k.191008.001. - DOI - PMC - PubMed
    1. Leslie S.W., Soon-Sutton T.L., Sajjad H., Siref L.E. StatPearls. StatPearls Publishing; Treasure Island, FL, USA: 2020. Prostate Cancer.

Publication types

MeSH terms