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Comment
. 2020 Nov 12;15(1):69.
doi: 10.1186/s13024-020-00417-0.

Activity of Alzheimer's γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity

Annie Y Yao  1 , Riqiang Yan  2
Affiliations
Comment

Activity of Alzheimer's γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity

Annie Y Yao et al. Mol Neurodegener. .

Abstract

The activity of γ-secretase is critical to the pathogenesis of Alzheimer's disease (AD). How its activity is regulated is intriguing and highly important for any AD therapy that focuses on reduction of toxic amyloid peptides and amyloid deposition in patients. Recently, interferon-induced transmembrane protein 3 (IFITM3) has been identified as a novel regulator of γ-secretase through a specific interaction. This commentary highlights this exciting study and provides an updated link of γ-secretase activity to innate immunity through IFITM3.

Keywords: Alzheimer’s disease; Amyloid plaques; IFITM3; Innate immunity; Interferon-induced transmembrane protein; Nicastrin; Photo-crosslinking; Presenilin; Γ-secretase.

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Conflict of interest statement

Authors declare no conflict of interest to this study.

Comment on

  • The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.
    Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM. Hur JY, et al. Nature. 2020 Oct;586(7831):735-740. doi: 10.1038/s41586-020-2681-2. Epub 2020 Sep 2. Nature. 2020. PMID: 32879487 Free PMC article.

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