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. 2020 Nov 13;52(11):1-11.
doi: 10.1017/S0033291720004080. Online ahead of print.

Association between common early-childhood infection and subsequent depressive symptoms and psychotic experiences in adolescence: a population-based longitudinal birth cohort study

Anna B Chaplin  1 , Peter B Jones  1   2 , Golam M Khandaker  1   2
Affiliations

Association between common early-childhood infection and subsequent depressive symptoms and psychotic experiences in adolescence: a population-based longitudinal birth cohort study

Anna B Chaplin et al. Psychol Med. .

Abstract

Background: Childhood infections are associated with adult psychosis and depression, but studies of psychotic experiences (PEs) and depressive symptoms in childhood, adolescence, and early-adulthood are scarce. Previous studies have typically examined severe infections, but studies of common infections are also scarce.

Methods: Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort, we examined associations of the number of infections in childhood from age 1.5 to 7.5 years with depressive symptom scores at age 10, 13, 14, 17, 18, and 19 years, and with PEs at 12 and 18 years. We performed additional analysis using infection burden ('low' = 0-4 infections, 'medium' = 5-6, 'high' = 7-9, or 'very high' = 10-22 infections) as the exposure.

Results: The risk set comprised 11 786 individuals with childhood infection data. Number of childhood infections was associated with depressive symptoms from age 10 (adjusted beta = 0.14; standard error (s.e.) = 0.04; p = <0.01) to 17 years (adjusted beta = 0.17; s.e. = 0.08; p = 0.04), and with PEs at age 12 (suspected/definite PEs: adjusted odds ratio (OR) = 1.18; 95% confidence interval (CI) = 1.09-1.27). These effect sizes were larger when the exposure was defined as very high infection burden (depressive symptoms age 17: adjusted beta = 0.79; s.e. = 0.29; p = 0.01; suspected/definite PEs at age 12: adjusted OR = 1.60; 95% CI = 1.25-2.05). Childhood infections were not associated with depressive/psychotic outcomes at age 18 or 19.

Conclusions: Common early-childhood infections are associated with depressive symptoms up to mid-adolescence and with PEs subsequently in childhood, but not with these outcomes in early-adulthood. These findings require replication including larger samples with outcomes in adulthood.

Keywords: ALSPAC; childhood infection; cohort study; depression; depressive symptoms; inflammation; psychosis; psychotic experiences.

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References

    1. Abel, K. M., Wicks, S., Susser, E. S., Dalman, C., Pedersen, M. G., Mortensen, P. B., & Webb, R. T. (2010). Birth weight, schizophrenia, and adult mental disorder: Is risk confined to the smallest babies? Archives of General Psychiatry, 67(9), 923–930. doi: 10.1001/archgenpsychiatry.2010.100. - DOI - PubMed
    1. Al-Haddad, B. J. S., Jacobsson, B., Chabra, S., Modzelewska, D., Olson, E. M., Bernier, R., … Sengpiel, V. (2019). Long-term risk of neuropsychiatric disease after exposure to infection in Utero. JAMA Psychiatry, 76(6), 594–602. doi: 10.1001/jamapsychiatry.2019.0029. - DOI - PMC - PubMed
    1. Bechter, K., Reiber, H., Herzog, S., Fuchs, D., Tumani, H., & Maxeiner, H. G. (2010). Cerebrospinal fluid analysis in affective and schizophrenic spectrum disorders: Identification of subgroups with immune responses and blood–CSF barrier dysfunction. Journal of Psychiatric Research, 44(5), 321–330. doi: 10.1016/j.jpsychires.2009.08.008. - DOI - PubMed
    1. Benros, M. E., Eaton, W. W., & Mortensen, P. B. (2014). The epidemiologic evidence linking autoimmune diseases and psychosis. Biological Psychiatry, 75(4), 300–306. doi: 10.1016/j.biopsych.2013.09.023. - DOI - PMC - PubMed
    1. Benros, M. E., Mortensen, P. B., & Eaton, W. W. (2012). Autoimmune diseases and infections as risk factors for schizophrenia. Annals of the New York Academy of Sciences, 1262(1), 56–66. doi: 10.1111/j.1749-6632.2012.06638.x. - DOI - PubMed