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Review
. 2021 Jan;46(1):2-4.
doi: 10.1016/j.tibs.2020.10.007. Epub 2020 Nov 9.

The Trinity of SPRTN Protease Regulation

Annamaria Ruggiano  1 , Kristijan Ramadan  2
Affiliations
Review

The Trinity of SPRTN Protease Regulation

Annamaria Ruggiano et al. Trends Biochem Sci. 2021 Jan.

Abstract

The protease SPRTN emerged as the essential enzyme for DNA-protein crosslink proteolysis repair. Biochemical and cell biological work indicated that SPRTN is a nonspecific protease. Recent and independent studies from Lou, Stingele, and Ramadan reveal that SPRTN activity is modulated via three layers of regulation that make it selective for DNA-protein crosslinks.

Keywords: DNA–protein crosslinks; SPRTN protease; cancer; genomic instability.

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