Review
doi: 10.1016/j.tibs.2020.10.007.
Epub 2020 Nov 9.
The Trinity of SPRTN Protease Regulation
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- PMID: 33183910
- DOI: 10.1016/j.tibs.2020.10.007
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Review
The Trinity of SPRTN Protease Regulation
Trends Biochem Sci.
2021 Jan.
Abstract
The protease SPRTN emerged as the essential enzyme for DNA-protein crosslink proteolysis repair. Biochemical and cell biological work indicated that SPRTN is a nonspecific protease. Recent and independent studies from Lou, Stingele, and Ramadan reveal that SPRTN activity is modulated via three layers of regulation that make it selective for DNA-protein crosslinks.
Keywords: DNA–protein crosslinks; SPRTN protease; cancer; genomic instability.
Copyright © 2020 Elsevier Ltd. All rights reserved.
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