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. 2020 Nov;19(6):868-871.
doi: 10.1016/j.jcf.2020.10.003. Epub 2020 Nov 4.

The global impact of SARS-CoV-2 in 181 people with cystic fibrosis

Elliot McClenaghan  1 , Rebecca Cosgriff  2 , Keith Brownlee  2 , Susannah Ahern  3 , Pierre-Régis Burgel  4 , Catherine A Byrnes  5 , Carla Colombo  6 , Harriet Corvol  7 , Stephanie Y Cheng  8 , Géraldine Daneau  9 , Alexander Elbert  10 , Albert Faro  10 , Christopher H Goss  11 , Vincent Gulmans  12 , Hector Gutierrez  13 , Isabelle de Monestrol  14 , Andreas Jung  15 , Lutz Nährlich Justus  16 , Nataliya Kashirskaya  17 , Bruce C Marshall  10 , Edward McKone  18 , Peter G Middleton  19 , Pedro Mondejar-Lopez  20 , M Dolores Pastor-Vivero  21 , Rita Padoan  22 , Samar Rizvi  10 , Rasa Ruseckaite  3 , Marco Salvatore  23 , Anne L Stephenson  24 , Luiz Vicente R da Silva Filho  25 , Joel Melo  26 , Marco Zampoli  27 , Siobhán B Carr  28 ; Global Registry Harmonization Group
Collaborators, Affiliations

The global impact of SARS-CoV-2 in 181 people with cystic fibrosis

Elliot McClenaghan et al. J Cyst Fibros. 2020 Nov.

Abstract

With the growing SARS-CoV-2 pandemic, we need to better understand its impact in specific patient groups like those with Cystic Fibrosis (CF). We report on 181 people with CF (32 post-transplant) from 19 countries diagnosed with SARS-CoV-2 prior to 13 June 2020. Infection with SARS-CoV-2 appears to exhibit a similar spectrum of outcomes to that seen in the general population, with 11 people admitted to intensive care (7 post-transplant), and 7 deaths (3 post-transplant). A more severe clinical course may be associated with older age, CF-related diabetes, lower lung function in the year prior to infection, and having received an organ transplant. Whilst outcomes in this large cohort are better than initially feared overall, possibly due to a protective effect of the relatively younger age of the CF population compared to other chronic conditions, SARS-CoV-2 is not a benign disease for all people in this patient group.

Keywords: COVID-19; Coronavirus; Cystic fibrosis; SARS-CoV-2; Transplant.

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Conflict of interest statement

Declaration of Competing Interest The authors have no conflicts of interest to declare relating to this work.

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