Review

. 2021 May;76(5):503-507.

doi: 10.1136/thoraxjnl-2020-215884. Epub 2020 Nov 12.

Early-life risk factors for reversible and irreversible airflow limitation in young adults: findings from the BAMSE birth cohort

Gang Wang^{1

2

3}, Inger Kull^{2

3

4}, Anna Bergström^{2

5}, Jenny Hallberg^{3

4}, Petra Um Bergström^{3

4}, Stefano Guerra^{6

7}, Goran Pershagen^{2

5}, Olena Gruzieva^{2

5}, Marianne van Hage⁸, Antonios Georgelis^{2

5}, Christer Janson⁹, Anders Lindén^{2

10}, Erik Melén^{11

3

4}

Affiliations

¹ Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
² Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
³ Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
⁴ Sachs' Children's Hospital, Stockholm, Sweden.
⁵ Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden.
⁶ Asthma and Airway Disease Research Center, The University of Arizona, Tucson, Arizona, USA.
⁷ ISGLOBAL, Barcelona, Spain.
⁸ Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden.
⁹ Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
¹⁰ Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.
¹¹ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden erik.melen@ki.se.

PMID: 33184098
PMCID: PMC8070638
DOI: 10.1136/thoraxjnl-2020-215884

Review

Early-life risk factors for reversible and irreversible airflow limitation in young adults: findings from the BAMSE birth cohort

Gang Wang et al. Thorax. 2021 May.

. 2021 May;76(5):503-507.

doi: 10.1136/thoraxjnl-2020-215884. Epub 2020 Nov 12.

Authors

Affiliations

¹ Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
² Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
³ Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
⁴ Sachs' Children's Hospital, Stockholm, Sweden.
⁵ Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden.
⁶ Asthma and Airway Disease Research Center, The University of Arizona, Tucson, Arizona, USA.
⁷ ISGLOBAL, Barcelona, Spain.
⁸ Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden.
⁹ Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
¹⁰ Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.
¹¹ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden erik.melen@ki.se.

PMID: 33184098
PMCID: PMC8070638
DOI: 10.1136/thoraxjnl-2020-215884

Abstract

We aimed to determine prevalence and early-life risk factors for reversible and irreversible airflow limitation in young adults from the general population. Among young adults in their 20s, the prevalence was 5.3% for reversible airflow limitation and 2.0% for irreversible airflow limitation. While parental asthma was the only risk factor for development of reversible airflow limitation, the risk factors for development of irreversible airflow limitation were current asthma, childhood respiratory tract infections and asthma, and exposure to air pollution.

Keywords: COPD epidemiology.

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Conflict of interest statement

Competing interests: EM reports personal fees from Sanofi, Chiesi and AstraZeneca, outside the submitted work.

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Early-life risk factors for reversible and irreversible airflow limitation in young adults: findings from the BAMSE birth cohort

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Early-life risk factors for reversible and irreversible airflow limitation in young adults: findings from the BAMSE birth cohort

Authors

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Abstract

Conflict of interest statement

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