Machine learning in precision medicine: lessons to learn

Darren Plant^{1

2}, Anne Barton^{3

4}

Affiliations

¹ NIHR Manchester Biomedical Research Centre, Manchester University NHS Trust, Manchester Academic Health Science Centre, Manchester, UK.
² Versus Arthritis Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.
³ NIHR Manchester Biomedical Research Centre, Manchester University NHS Trust, Manchester Academic Health Science Centre, Manchester, UK. anne.barton@manchester.ac.uk.
⁴ Versus Arthritis Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK. anne.barton@manchester.ac.uk.

Comment

Darren Plant et al. Nat Rev Rheumatol. 2021 Jan.

. 2021 Jan;17(1):5-6.

doi: 10.1038/s41584-020-00538-2.

Darren Plant^{1

2}, Anne Barton^{3

4}

¹ NIHR Manchester Biomedical Research Centre, Manchester University NHS Trust, Manchester Academic Health Science Centre, Manchester, UK.
² Versus Arthritis Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.
³ NIHR Manchester Biomedical Research Centre, Manchester University NHS Trust, Manchester Academic Health Science Centre, Manchester, UK. anne.barton@manchester.ac.uk.
⁴ Versus Arthritis Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK. anne.barton@manchester.ac.uk.

No abstract available

Comment on

Multiomics and Machine Learning Accurately Predict Clinical Response to Adalimumab and Etanercept Therapy in Patients With Rheumatoid Arthritis.
Tao W, Concepcion AN, Vianen M, Marijnissen ACA, Lafeber FPGJ, Radstake TRDJ, Pandit A. Tao W, et al. Arthritis Rheumatol. 2021 Feb;73(2):212-222. doi: 10.1002/art.41516. Epub 2020 Dec 26. Arthritis Rheumatol. 2021. PMID: 32909363 Free PMC article.

1. Tao, W. et al. Multi-omics and machine learning accurately predicts clinical response to adalimumab and etanercept therapy in patients with rheumatoid arthritis. Arthritis Rheumatol. https://doi.org/10.1002/art.41516 (2020). - DOI - PubMed
1. National Center for Biotechnology Information. Gene expression omnibus database https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE138747 (2020).
1. Riley, R. D. et al. Minimum sample size for developing a multivariable prediction model: PART II - binary and time-to-event outcomes. Stat. Med. 38, 1276–1296 (2019). - DOI
1. Guyon, I. & Elisseeff, A. An introduction to variable and feature selection. J. Mach. Learn. Res. 3, 157–1182 (2003).
1. Ball, T. M. et al. Double dipping in machine learning: problems and solutions. Biol. Psychiatry Cogn. Neurosci. Neuroimaging 5, 261–263 (2020). - PubMed