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. 2020;78(4):1519-1546.
doi: 10.3233/JAD-201069.

Associations Between Caffeine Consumption, Cognitive Decline, and Dementia: A Systematic Review

J Q Alida Chen  1 , Philip Scheltens  1 , Colin Groot  1 , Rik Ossenkoppele  1   2
Affiliations

Associations Between Caffeine Consumption, Cognitive Decline, and Dementia: A Systematic Review

J Q Alida Chen et al. J Alzheimers Dis. 2020.

Abstract

Background: Epidemiologic studies have provided inconclusive evidence for a protective effect of caffeine consumption on risk of dementia and cognitive decline.

Objective: To summarize literature on the association between caffeine and 1) the risk of dementia and/or cognitive decline, and 2) cognitive performance in individuals with mild cognitive impairment (MCI) or dementia, and 3) to examine the effect of study characteristics by categorizing studies based on caffeine source, quantity and other possible confounders.

Methods: We performed a systematic review of caffeine effects by assessing overall study outcomes; positive, negative or no effect. Our literature search identified 61 eligible studies performed between 1990 and 2020.

Results: For studies analyzing the association between caffeine and the risk of dementia and/or cognitive decline, 16/57 (28%) studies including a total of 40,707/153,070 (27%) subjects reported positive study outcomes, and 30/57 (53%) studies including 71,219/153,070 (47%) subjects showed positive results that were dependent on study characteristics. Caffeine effects were more often positive when consumed in moderate quantities (100-400 mg/d), consumed in coffee or green tea, and in women. Furthermore, four studies evaluated the relationship between caffeine consumption and cognitive function in cognitively impaired individuals and the majority (3/4 [75% ]) of studies including 272/289 subjects (94%) reported positive outcomes.

Conclusion: This review suggests that caffeine consumption, especially moderate quantities consumed through coffee or green tea and in women, may reduce the risk of dementia and cognitive decline, and may ameliorate cognitive decline in cognitively impaired individuals.

Keywords: Caffeine; coffee; cognition; dementia; review; tea.

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Conflict of interest statement

Authors’ disclosures available online (https://www.j-alz.com/manuscript-disclosures/20-1069).

Figures

Fig. 1
Fig. 1
Flow diagram of identification of relevant studies.
Fig. 2
Fig. 2
Risk of bias assessment of the included studies.
Fig. 3
Fig. 3
A Study outcomes for the association between caffeine and dementia and/or cognitive function. Pie charts show study outcomes based on population, caffeine consumption dosage and type of caffeine source: positive effect (darker green), positive effect dependent on study characteristics (lighter green), no effect (gray), and negative effect (red [none observed]). Outlined charts indicate a predominant positive outcome.
Fig. 3
Fig. 3
B Study outcomes for the association between caffeine and dementia and/or cognitive function of the included subjects. Pie charts show study outcomes based on population, caffeine consumption dosage and type of caffeine source: positive effect (darker green), positive effect dependent on study characteristics (lighter green), no effect (gray), and negative effect (red [none observed]). Outlined charts indicate a predominant positive outcome.
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