Evaluating the clinical utility and sensitivity of SARS-CoV-2 antigen testing in relation to RT-PCR Ct values

doi:10.1007/s15010-020-01542-0

. 2021 Jun;49(3):555-557.

doi: 10.1007/s15010-020-01542-0. Epub 2020 Nov 13.

Evaluating the clinical utility and sensitivity of SARS-CoV-2 antigen testing in relation to RT-PCR Ct values

Lukas Lanser¹, Rosa Bellmann-Weiler¹, Karla-Wanda Öttl¹, Lukas Huber¹, Andrea Griesmacher², Igor Theurl¹, Günter Weiss³

Affiliations

¹ Department of Internal Medicine II, Innsbruck Medical University, Anichstraße 35, 6020, Innsbruck, Austria.
² Central Institute for Medical and Chemical Laboratory Diagnosis, Innsbruck University Hospital, Innsbruck, Austria.
³ Department of Internal Medicine II, Innsbruck Medical University, Anichstraße 35, 6020, Innsbruck, Austria. guenter.weiss@i-med.ac.at.

PMID: 33185807
PMCID: PMC7662025
DOI: 10.1007/s15010-020-01542-0

Evaluating the clinical utility and sensitivity of SARS-CoV-2 antigen testing in relation to RT-PCR Ct values

Lukas Lanser et al. Infection. 2021 Jun.

. 2021 Jun;49(3):555-557.

doi: 10.1007/s15010-020-01542-0. Epub 2020 Nov 13.

Authors

Lukas Lanser¹, Rosa Bellmann-Weiler¹, Karla-Wanda Öttl¹, Lukas Huber¹, Andrea Griesmacher², Igor Theurl¹, Günter Weiss³

Affiliations

¹ Department of Internal Medicine II, Innsbruck Medical University, Anichstraße 35, 6020, Innsbruck, Austria.
² Central Institute for Medical and Chemical Laboratory Diagnosis, Innsbruck University Hospital, Innsbruck, Austria.
³ Department of Internal Medicine II, Innsbruck Medical University, Anichstraße 35, 6020, Innsbruck, Austria. guenter.weiss@i-med.ac.at.

PMID: 33185807
PMCID: PMC7662025
DOI: 10.1007/s15010-020-01542-0

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Comment in

Rapid antigen testing and non-infectious shedding of SARS-Cov2.
Weiss G, Bellmann-Weiler R. Weiss G, et al. Infection. 2021 Aug;49(4):789-790. doi: 10.1007/s15010-020-01570-w. Epub 2021 Jan 2. Infection. 2021. PMID: 33386584 Free PMC article. No abstract available.
Antigen testing and non-infectious shedding of SARS-COV-2.
Raveh Y, Simkins J, Nicolau-Raducu R. Raveh Y, et al. Infection. 2021 Aug;49(4):795-796. doi: 10.1007/s15010-021-01579-9. Epub 2021 Feb 10. Infection. 2021. PMID: 33566319 Free PMC article. No abstract available.

Cited by

Evaluation of Four Strategies for SARS-CoV-2 Detection: Characteristics and Prospects.
Chen Y, Ma Y, Han Y, Diao Z, Chang L, Li J, Zhang R. Chen Y, et al. Microbiol Spectr. 2022 Dec 21;10(6):e0214322. doi: 10.1128/spectrum.02143-22. Epub 2022 Oct 26. Microbiol Spectr. 2022. PMID: 36287010 Free PMC article.
Evaluation of a chemiluminescent enzyme immunoassay-based high-throughput SARS-CoV-2 antigen assay for the diagnosis of COVID-19: The VITROS® SARS-CoV-2 Antigen Test.
Matsuzaki N, Orihara Y, Kodana M, Kitagawa Y, Matsuoka M, Kawamura R, Takeuchi S, Imai K, Tarumoto N, Maesaki S, Maeda T. Matsuzaki N, et al. J Med Virol. 2021 Dec;93(12):6778-6781. doi: 10.1002/jmv.27153. Epub 2021 Aug 12. J Med Virol. 2021. PMID: 34170555 Free PMC article.
Rapid and Sensitive Detection of Antigen from SARS-CoV-2 Variants of Concern by a Multivalent Minibinder-Functionalized Nanomechanical Sensor.
Agarwal DK, Hunt AC, Shekhawat GS, Carter L, Chan S, Wu K, Cao L, Baker D, Lorenzo-Redondo R, Ozer EA, Simons LM, Hultquist JF, Jewett MC, Dravid VP. Agarwal DK, et al. Anal Chem. 2022 Jun 14;94(23):8105-8109. doi: 10.1021/acs.analchem.2c01221. Epub 2022 Jun 2. Anal Chem. 2022. PMID: 35652578 Free PMC article.
Proposed Framework for Considering SARS-CoV-2 Antigen Testing of Unexposed Asymptomatic Workers in Selected Workplaces.
Schulte PA, Piacentino JD, Weissman DN, de Perio MA, Chiu SK, Radonovich LJ, Trout D, Beezhold D, Hearl FJ, Howard J. Schulte PA, et al. J Occup Environ Med. 2021 Aug 1;63(8):646-656. doi: 10.1097/JOM.0000000000002269. J Occup Environ Med. 2021. PMID: 34016912 Free PMC article.
Evaluation of the Elecsys SARS-CoV-2 antigen assay for the detection of SARS-CoV-2 in nasopharyngeal swabs.
Ben Abdelhanin M, Mvumbi DM, Agathine A, Nanos N, Gidenne S. Ben Abdelhanin M, et al. J Clin Virol. 2021 Nov;144:104991. doi: 10.1016/j.jcv.2021.104991. Epub 2021 Oct 1. J Clin Virol. 2021. PMID: 34626880 Free PMC article.

See all "Cited by" articles

References

1. World Health Organisation. Laboratory testing for coronavirus disease (COVID-19) in suspected human cases: WHO/COVID-19/laboratory/2020.5. https://www.who.int/publications/i/item/10665-331501
1. Bullard J, Dust K, Funk D, Strong JE, Alexander D, Garnett L, et al. Predicting infectious SARS-CoV-2 from diagnostic samples. Clin Infect Dis. 2020 doi: 10.1093/cid/ciaa638. - DOI - PMC - PubMed
1. Walsh KA, Jordan K, Clyne B, Rohde D, Drummond L, Byrne P, et al. SARS-CoV-2 detection, viral load and infectivity over the course of an infection. J Infect. 2020;81:357–371. doi: 10.1016/j.jinf.2020.06.067. - DOI - PMC - PubMed
1. Rao SN, Manissero D, Steele VR, Pareja J. A systematic review of the clinical utility of cycle threshold values in the context of COVID-19. Infect Dis Ther. 2020;9:573–586. doi: 10.1007/s40121-020-00324-3. - DOI - PMC - PubMed
1. Dzien A, Dzien-Bischinger C, Lechleitner M, Winner H, Weiss G. Will the COVID-19 pandemic slow down in the Northern hemisphere by the onset of summer? An epidemiological hypothesis. Infection. 2020;48:627–629. doi: 10.1007/s15010-020-01460-1. - DOI - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information
Miscellaneous
- NCI CPTAC Assay Portal

[1] World Health Organisation. Laboratory testing for coronavirus disease (COVID-19) in suspected human cases: WHO/COVID-19/laboratory/2020.5. https://www.who.int/publications/i/item/10665-331501

[2] World Health Organisation. Laboratory testing for coronavirus disease (COVID-19) in suspected human cases: WHO/COVID-19/laboratory/2020.5. https://www.who.int/publications/i/item/10665-331501

[3] Bullard J, Dust K, Funk D, Strong JE, Alexander D, Garnett L, et al. Predicting infectious SARS-CoV-2 from diagnostic samples. Clin Infect Dis. 2020 doi: 10.1093/cid/ciaa638. - DOI - PMC - PubMed

[4] Bullard J, Dust K, Funk D, Strong JE, Alexander D, Garnett L, et al. Predicting infectious SARS-CoV-2 from diagnostic samples. Clin Infect Dis. 2020 doi: 10.1093/cid/ciaa638. - DOI - PMC - PubMed

[5] Walsh KA, Jordan K, Clyne B, Rohde D, Drummond L, Byrne P, et al. SARS-CoV-2 detection, viral load and infectivity over the course of an infection. J Infect. 2020;81:357–371. doi: 10.1016/j.jinf.2020.06.067. - DOI - PMC - PubMed

[6] Walsh KA, Jordan K, Clyne B, Rohde D, Drummond L, Byrne P, et al. SARS-CoV-2 detection, viral load and infectivity over the course of an infection. J Infect. 2020;81:357–371. doi: 10.1016/j.jinf.2020.06.067. - DOI - PMC - PubMed

[7] Rao SN, Manissero D, Steele VR, Pareja J. A systematic review of the clinical utility of cycle threshold values in the context of COVID-19. Infect Dis Ther. 2020;9:573–586. doi: 10.1007/s40121-020-00324-3. - DOI - PMC - PubMed

[8] Rao SN, Manissero D, Steele VR, Pareja J. A systematic review of the clinical utility of cycle threshold values in the context of COVID-19. Infect Dis Ther. 2020;9:573–586. doi: 10.1007/s40121-020-00324-3. - DOI - PMC - PubMed

[9] Dzien A, Dzien-Bischinger C, Lechleitner M, Winner H, Weiss G. Will the COVID-19 pandemic slow down in the Northern hemisphere by the onset of summer? An epidemiological hypothesis. Infection. 2020;48:627–629. doi: 10.1007/s15010-020-01460-1. - DOI - PMC - PubMed

[10] Dzien A, Dzien-Bischinger C, Lechleitner M, Winner H, Weiss G. Will the COVID-19 pandemic slow down in the Northern hemisphere by the onset of summer? An epidemiological hypothesis. Infection. 2020;48:627–629. doi: 10.1007/s15010-020-01460-1. - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Evaluating the clinical utility and sensitivity of SARS-CoV-2 antigen testing in relation to RT-PCR Ct values

Affiliations

Evaluating the clinical utility and sensitivity of SARS-CoV-2 antigen testing in relation to RT-PCR Ct values

Authors

Affiliations

Conflict of interest statement

Comment in

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous