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. 2021 May 1;32(3):241-246.
doi: 10.1097/MCA.0000000000000989.

Safety and efficacy of coronary laser ablation as an adjunctive therapy in percutaneous coronary intervention: a single-centre experience

Mohsen Mohandes  1 , Laura Fernández, Sergio Rojas, Cristina Moreno, Mónica Fuertes, Francisco Fernández, Alberto Pernigotti, Maribel Gonzalez-Del-Hoyo, Jordi Guarinos, Esther Sanz, Alfredo Bardají
Affiliations

Safety and efficacy of coronary laser ablation as an adjunctive therapy in percutaneous coronary intervention: a single-centre experience

Mohsen Mohandes et al. Coron Artery Dis. .

Abstract

Background: Coronary laser is a long-established coadjuvant therapy in interventional cardiology. This study aimed to present our experience regarding the safety and efficacy of laser assistance to percutaneous coronary intervention (PCI) in different scenarios of coronary artery disease.

Methods: We used coronary laser as an adjunctive therapy for PCI between May 2014 and March 2020. The safety of laser ablation was evaluated by studying any complication associated with the laser application. Besides, the laser contribution to PCI and 1 year of follow-up for adverse cardiac events was studied.

Results: Coronary laser was performed in 81 lesions and 75 patients in different scenarios to assist PCI. The average age was 66 ± 11.7 years and 72 (88.9%) were men. Coronary laser was used in 30 (37%) cases for in-stent-material debulking; 26 (32.1%) in primary angioplasty, 19 (23.4%) in chronic total occlusion and 5 (6.2%) in saphenous vein grafts. Procedural success was achieved in 77 (95.1%) with 1 (1.2%) type III coronary perforation. One year of follow-up for combined adverse cardiac events consisting of death due to any cause, myocardial infarction or target vessel failure showed an event-free rate of 0.82 (95% confidence interval, 0.72-0.91).

Conclusions: Our preliminary experience reveals the safety and efficacy of the current modality of coronary laser as a coadjuvant therapy in PCI with a low rate of adverse cardiac events in 1-year of follow-up. Further studies are needed to establish more precisely the contribution of laser application in different contexts of coronary artery disease.

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References

    1. Choy DSJ. History and state-of-the-art of lasers in cardiovascular disease. Laser Med Surg News Advances. 1988; 6:34–38.
    1. Cook SL, Eigler NL, Shefer A, Goldenberg T, Forrester JS, Litvack F. Percutaneous excimer laser coronary angioplasty of lesions not ideal for balloon angioplasty. Circulation. 1991; 84:632–643.
    1. Litvack F, Grundfest WS, Papaioannou T, Mohr FW, Jakubowski AT, Forrester JS. Role of laser and thermal ablation devices in the treatment of vascular diseases. Am J Cardiol. 1988; 61:81G–86G.
    1. Topaz O. Plaque removal and thrombus dissolution with the photoacoustic energy of pulsed-wave lasers-biotissue interactions and their clinical manifestations. Cardiology. 1996; 87:384–391.
    1. Grundfest WS, Litvack F, Forrester JS, Goldenberg T, Swan HJ, Morgenstern L, et al. Laser ablation of human atherosclerotic plaque without adjacent tissue injury. J Am Coll Cardiol. 1985; 5:929–933.