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Comment
. 2020 Nov 24;4(22):5631-5634.
doi: 10.1182/bloodadvances.2020003168.

Malignant progression of donor-engrafted clonal hematopoiesis in sibling recipients after stem cell transplantation

Louis Nevejan  1 , Friedel Nollet  1 , Helena Devos  1 , Matthijs Vynck  1 , Pieter Van Vlierberghe  2 , Mercedeh Tajdar  1 , Tom Lodewyck  3 , Dominik Selleslag  3
Affiliations
Comment

Malignant progression of donor-engrafted clonal hematopoiesis in sibling recipients after stem cell transplantation

Louis Nevejan et al. Blood Adv. .
No abstract available

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.
Evolution of JAK2 p.(V617F) mutational burden (%) in peripheral blood from donor and recipient as described in case 1. Donor, blue dashed line (Δ); MDS-EB2, MDS with excess blasts-2; PV, polycythemia vera; recipient,  red full line (•); sWGS, shallow whole-genome sequencing; Tx, transplantation.
Figure 2.
Figure 2.
Sequencing data of both donor and recipient after allogeneic hematopoietic stem cell transplantation at time of diagnosis of DCHN. NGS was performed by using a panel of 21 genes relevant to myeloid malignancies. Shallow whole-genome sequencing (sWGS) was performed only of both donor and recipient samples as described in case 1 (details are provided in the supplemental Data). Definitions of hematologic neoplasms are according to the updated (2016) World Health Organization classification and to Valent et al. AML-M2, acute myeloid leukemia with maturation; AML-M5, acute monoblastic leukemia; Dx, diagnosis; CHIP, CH of indeterminate potential; MDS-MLD, MDS with multilineage dysplasia; MDS-RS-MLD, MDS with ring sideroblasts and multilineage dysplasia; yo, years old.
See this image and copyright information in PMC

Comment on

References

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