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Review
. 2020 Nov 11;25(22):5243.
doi: 10.3390/molecules25225243.

Important Flavonoids and Their Role as a Therapeutic Agent

Asad Ullah  1 , Sidra Munir  1 , Syed Lal Badshah  1 , Noreen Khan  1 , Lubna Ghani  2 , Benjamin Gabriel Poulson  3 , Abdul-Hamid Emwas  4 , Mariusz Jaremko  3
Affiliations
Review

Important Flavonoids and Their Role as a Therapeutic Agent

Asad Ullah et al. Molecules. .

Abstract

Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of medicinal benefits, including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects. These biological activities depend upon the type of flavonoid, its (possible) mode of action, and its bioavailability. These cost-effective medicinal components have significant biological activities, and their effectiveness has been proved for a variety of diseases. The most recent work is focused on their isolation, synthesis of their analogs, and their effects on human health using a variety of techniques and animal models. Thousands of flavonoids have been successfully isolated, and this number increases steadily. We have therefore made an effort to summarize the isolated flavonoids with useful activities in order to gain a better understanding of their effects on human health.

Keywords: antioxidative; flavonoids; neuroprotective; polyphenols; quercetin.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Chemical structure of flavonoids and its different types.
Figure 2
Figure 2
Flavonoid compound isolated from Sinopodophylli fructus.
Figure 3
Figure 3
Chemical structure of 4′-hydroxy-6,7-methylenedioxy-3-methoxyflavone.
Figure 4
Figure 4
Chemical structure of dihydroxy-8-methoxyflavone (wogonin).
Figure 5
Figure 5
Chemical structure of luteolin.
Figure 6
Figure 6
Lead compound of flavonolignan exhibiting antioxidant and antidiabetic activity.
Figure 7
Figure 7
Quercetin-3-O-glucoside (Left side) and luteolin-7-O-β-d-glucuronide (Right side).
Figure 8
Figure 8
Kaempferol identified in Stachys cretica.
Figure 9
Figure 9
Chemical structures of glabranine and 7-O-methyl-glabranine.
Figure 10
Figure 10
Flavonoids of Bridelia extract.
Figure 11
Figure 11
Chemical structure of 2′,4′-dihydroxy-5′-(1‴,1‴-dimethylallyl)-8-prenyl pinocembrin (8PP).
See this image and copyright information in PMC

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