Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Nov 11;10(11):171.
doi: 10.3390/bios10110171.

The Role of Electronic Noses in Phenotyping Patients with Chronic Obstructive Pulmonary Disease

Simone Scarlata  1 , Panaiotis Finamore  2 , Martina Meszaros  3 , Silvano Dragonieri  4 , Andras Bikov  5   6
Affiliations
Review

The Role of Electronic Noses in Phenotyping Patients with Chronic Obstructive Pulmonary Disease

Simone Scarlata et al. Biosensors (Basel). .

Abstract

Chronic obstructive pulmonary disease (COPD) is a common progressive disorder of the respiratory system which is currently the third leading cause of death worldwide. Exhaled breath analysis is a non-invasive method to study lung diseases, and electronic noses have been extensively used in breath research. Studies with electronic noses have proved that the pattern of exhaled volatile organic compounds is different in COPD. More recent investigations have reported that electronic noses could potentially distinguish different endotypes (i.e., neutrophilic vs. eosinophilic) and are able to detect microorganisms in the airways responsible for exacerbations. This article will review the published literature on electronic noses and COPD and help in identifying methodological, physiological, and disease-related factors which could affect the results.

Keywords: COPD; VOCs; chronic obstructive pulmonary disease; e-nose; electronic nose; volatile organic compounds.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The pathophysiology of chronic obstructive pulmonary disease.
Figure 2
Figure 2
Algorithm for the exhaled breath collection and analysis with electronic nose.
Figure 3
Figure 3
The mechanisms of altered production of exhaled volatile organic compounds (VOCs) in COPD.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Vogelmeier C.F., Criner G.J., Martinez F.J., Anzueto A., Barnes P.J., Bourbeau J., Celli B.R., Chen R., Decramer M., Fabbri L.M., et al. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary. Eur. Respir. J. 2017;49:1700214. doi: 10.1183/13993003.00214-2017. - DOI - PubMed
    1. Barnes P.J., Burney P.G., Silverman E.K., Celli B.R., Vestbo J., Wedzicha J.A., Wouters E.F. Chronic obstructive pulmonary disease. Nat. Rev. Dis. Primers. 2015;1:15076. doi: 10.1038/nrdp.2015.76. - DOI - PubMed
    1. Lange P., Celli B., Agusti A., Boje Jensen G., Divo M., Faner R., Guerra S., Marott J.L., Martinez F.D., Martinez-Camblor P., et al. Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease. N. Engl. J. Med. 2015;373:111–122. doi: 10.1056/NEJMoa1411532. - DOI - PubMed
    1. Hurst J.R., Vestbo J., Anzueto A., Locantore N., Mullerova H., Tal-Singer R., Miller B., Lomas D.A., Agusti A., Macnee W., et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N. Engl. J. Med. 2010;363:1128–1138. doi: 10.1056/NEJMoa0909883. - DOI - PubMed
    1. Pascoe S., Locantore N., Dransfield M.T., Barnes N.C., Pavord I.D. Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: A secondary analysis of data from two parallel randomised controlled trials. Lancet. Respir. Med. 2015;3:435–442. doi: 10.1016/S2213-2600(15)00106-X. - DOI - PubMed

Substances