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. 2020 Nov 13;18(1):88.
doi: 10.1186/s12969-020-00485-y.

Longitudinal assessment of racial disparities in juvenile idiopathic arthritis disease activity in a treat-to-target intervention

Joyce C Chang  1   2   3 , Rui Xiao  4   5 , Jon M Burnham  6   4   7 , Pamela F Weiss  6   8   4   9
Affiliations

Longitudinal assessment of racial disparities in juvenile idiopathic arthritis disease activity in a treat-to-target intervention

Joyce C Chang et al. Pediatr Rheumatol Online J. .

Abstract

Background: We sought to evaluate racial disparities in disease outcomes among children with polyarticular juvenile idiopathic arthritis (JIA) during a treat-to-target (TTT) intervention with clinical decision support (CDS).

Methods: This was a retrospective analysis of a TTT-CDS strategy integrated into clinical practice for children with polyarticular JIA at a single center from 2016 to 2019. The primary outcome was the clinical Juvenile Arthritis Disease Activity Score (cJADAS-10). We used multivariable linear regression to assess racial differences in disease outcomes at the index visit (first visit after implementation). The effect of race on disease outcomes over time was estimated using linear mixed-effects models, stratified by incident or prevalent disease.

Results: We included 159 children with polyarticular JIA, of which 74, 13 and 13% were white, black, and Asian/other, respectively. cJADAS-10 improved significantly over time for all race categories, while the rates of improvement did not differ by race in incident (p = 0.53) or prevalent cases (p = 0.58). cJADAS-10 over time remained higher among black children compared to white children (β 2.5, p < 0.01 and β 1.2, p = 0.08 for incident and prevalent cases, respectively). Provider attestation to CDS use at ≥50% of encounters was associated with a 3.9 greater reduction in cJADAS-10 among black children compared to white children (p = 0.02).

Conclusion: Despite similar rates of improvement over time by race, disparities in JIA outcomes persisted throughout implementation of a TTT-CDS approach. More consistent CDS use may have a greater benefit among black children and needs to be explored further.

Keywords: Healthcare disparities; Juvenile arthritis; Patient outcome assessment; Patient reported outcome measures; Pediatrics.

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Conflict of interest statement

J.C. and J.B. report grant funding from GlaxoSmithKline for research outside of this work. The remaining listed authors declare they have no competing interests.

Figures

Fig. 1
Fig. 1
Predicted margins of disease activity over time by race in incident JIA. Predicted mean disease activity scores over time among incident polyarticular JIA cases by race, with 95% confidence intervals from the linear mixed-effects regression model, at means of all other covariates (age, baseline cJADAS score, RF positivity, non-biologic DMARD use, biologic use)
Fig. 2
Fig. 2
Predicted margins of disease activity over time by race in prevalent JIA. Predicted mean disease activity scores over time among prevalent polyarticular JIA cases by race, with 95% confidence intervals from the linear mixed-effects regression model, at means of all other covariates (baseline cJADAS score, insurance status, biologic use)
Fig. 3
Fig. 3
Marginal effects of race on pain and physical function over time. Marginal effects of race on pain, PROMIS® mobility, and PROMIS® upper extremity scores over time among incident and prevalent polyarticular JIA cases. Each beta coefficient is derived from a separate multivariable linear mixed-effects model, representing the mean difference over time in the outcome for each racial category compared to white race (reference group). Bars represent 95% confidence intervals
See this image and copyright information in PMC

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