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Comment
. 2021 Jan;11(1):11.
doi: 10.1158/2159-8290.CD-RW2020-166. Epub 2020 Nov 13.

Cell Lines Recapitulate Intratumoral Heterogeneity Observed In Vivo

No authors listed
Comment

Cell Lines Recapitulate Intratumoral Heterogeneity Observed In Vivo

No authors listed. Cancer Discov. 2021 Jan.

Abstract

Cancer cell lines often used in research had transcriptomic heterogeneity reminiscent of tumors.

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  • Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity.
    Kinker GS, Greenwald AC, Tal R, Orlova Z, Cuoco MS, McFarland JM, Warren A, Rodman C, Roth JA, Bender SA, Kumar B, Rocco JW, Fernandes PACM, Mader CC, Keren-Shaul H, Plotnikov A, Barr H, Tsherniak A, Rozenblatt-Rosen O, Krizhanovsky V, Puram SV, Regev A, Tirosh I. Kinker GS, et al. Nat Genet. 2020 Nov;52(11):1208-1218. doi: 10.1038/s41588-020-00726-6. Epub 2020 Oct 30. Nat Genet. 2020. PMID: 33128048 Free PMC article.

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